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Carnosine is a compound formed from two amino acids (histidine and alanine) and is found in several organ systems including muscle and brain. A number of possible biological roles for this compound have been suggested including antioxidant properties. It has been used experimentally in several disorders. One small double-blind study in 2002 by Chez and colleagues reported positive initial findings, although the study was criticized on various grounds and the results have not yet been well replicated in the scientific literature.
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Chez, M. G., Buchanan, C. P., Aimonovitch, M. C., Becker, M., Schaefer, K., Black, C., & Komen, J. (2002). Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders. Journal of Child Neurology, 17(11), 833–837.
Levy, S. E., & Hyman, S. L. (2005). Novel treatments for autistic spectrum disorders. Mental Retardation and Developmental Disabilities Research Reviews, 11(2), 131–142.
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Volkmar, F.R. (2020). Carnosine. In: Volkmar, F. (eds) Encyclopedia of Autism Spectrum Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6435-8_1384-3
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DOI: https://doi.org/10.1007/978-1-4614-6435-8_1384-3
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