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Laser Speckle Imaging of Cerebral Blood Flow

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Abstract

Monitoring the spatio-temporal characteristics of cerebral blood flow (CBF) is crucial for studying the normal and pathophysiologic conditions of brain metabolism. By illuminating the cortex with laser light and imaging the resulting speckle pattern, relative CBF images with tens of microns spatial and millisecond temporal resolution could be obtained. In this chapter, a laser speckle imaging (LSI) method for monitoring dynamic, high-resolution CBF is introduced. Its applications on detecting the change in local CBF induced by sensory stimulation and the influence of a chemical agent to CBF are given. To improve the spatial resolution of current LSI, a modified LSI method is proposed. Dynamic of CBF under different temperatures is investigated by both methods and their results are compared with each other.

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Authors and Affiliations

  1. Huazhong University of Science and Technology, Wuhan, 430074, P.R. China

    Qingming Luo, Haiying Cheng & Zheng Wang

  2. Saratov State University, Saratov, 410012, Russian Federation

    Valery V. Tuchin

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  1. Qingming Luo
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  2. Haiying Cheng
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  3. Zheng Wang
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  4. Valery V. Tuchin
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Editors and Affiliations

  1. Precision Mechanics and Control Institute of the Russian Academy of Sciences, Saratov State University, Saratov, 410012, Russian Federation

    Valery V. Tuchin

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© 2004 Kluwer Academic Publishers

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Luo, Q., Cheng, H., Wang, Z., Tuchin, V.V. (2004). Laser Speckle Imaging of Cerebral Blood Flow. In: Tuchin, V.V. (eds) Handbook of Coherent Domain Optical Methods. Springer, New York, NY. https://doi.org/10.1007/0-387-29989-0_5

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  • DOI: https://doi.org/10.1007/0-387-29989-0_5

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