Table of contents

  1. Front Matter
    Pages i-xxxiii
  2. Section 1 Cerebellar Development

    1. Front Matter
      Pages 1-1
    2. G. Giacomo Consalez, Marta Florio, Luca Massimino, Laura Croci
      Pages 23-41
    3. Roy V. Sillitoe, Richard Hawkes
      Pages 43-59
    4. Victor V. Chizhikov
      Pages 61-74
    5. Mikio Hoshino, Yusuke Seto, Mayumi Yamada
      Pages 75-87
    6. Thomas Butts, Leigh Wilson, Richard J. T. Wingate
      Pages 89-106
    7. Yutaro Komuro, Jennifer K. Fahrion, Kathryn D. Foote, Kathleen B. Fenner, Tatsuro Kumada, Nobuhiko Ohno et al.
      Pages 107-125
    8. Constantino Sotelo, Ferdinando Rossi
      Pages 147-178
    9. Gina E. Elsen, Gordana Juric-Sekhar, Ray A. M. Daza, Robert F. Hevner
      Pages 179-205
    10. Marco Sassoè-Pognetto, Annarita Patrizi
      Pages 237-255
    11. Ann M. Lohof, Mathieu Letellier, Jean Mariani, Rachel M. Sherrard
      Pages 257-279
    12. Masanobu Kano, Masahiko Watanabe
      Pages 281-299
    13. Matt Larouche, Daniel Goldowitz
      Pages 301-317
    14. Noriyuki Koibuchi, Yayoi Ikeda
      Pages 319-339
  3. Section 2 Anatomy, Connections and Neuroimaging of the Cerebellum

    1. Front Matter
      Pages 341-341

About this book

Introduction

Our knowledge of cerebellar functions and cerebellar disorders, called ataxias, is increasing considerably. Studies of the cerebellum are now a central focus in neuroscience. During the last four decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and biology of mental processes, behavioral symptoms, and emotion. It is now accepted that the cerebellum acts as a cognitive operator in learning, perception, and attention. Moreover, major improvements in our assessment of in vivo cerebellar architecture using imaging techniques have occurred. A typical example is the accurate description of cerebellar anatomy during fetal development with MRI, a progress which has direct impacts on patient care. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias. More than 20 new genes have been identified these last 10 years. Only for dominant ataxias, more than 30 diseases have now been unravelled. The number of ataxic disorders will increase with aging, the cerebellum being the structure of the brain with the most important loss of neurons with age. More than 300 different cerebellar disorders are encountered during daily practice, but we are missing a single source of information explaining their pathogenesis. Despite the immense amount of knowledge acquired about the cerebellar circuitry these last years, a large book covering the neuroscience of the cerebellum is missing. The goal of this endeavour is to bring up to date information relevant for basic science and also for clinical activities. To reach this goal, the most renowned authors are gathered in a unique and in-depth book with a format of a handbook. We emphasize the connections between molecular findings, imaging features, behavioural/neuropsychological aspects, and clinical implications.

Keywords

Ataxia Cerebellar disorders Neuroscience Sensorimotor processing and motor diseases Society for Research on the Cerebellum

Editors and affiliations

  • Mario Manto
    • 1
  • Jeremy D. Schmahmann
    • 2
  • Ferdinando Rossi
    • 3
  • Donna L. Gruol
    • 4
  • Noriyuki Koibuchi
    • 5
  1. 1.Unité d'Etude du Mouvement (UEM)FNRS, Neurologie ULB ErasmeBruxellesBelgium
  2. 2.Ataxia Unit, Cognitive and Behavioral Neurology Unit, Department of NeurologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  3. 3.Neuroscience Institute of the Cavalieri-Ottolenghi Foundation (NICO)University of TurinOrbassanoItaly
  4. 4.Molecular and Integrative Neuroscience Department (MIND)The Scripps Research InstituteCaliforniaUSA
  5. 5.Department of Integrative PhysiolgyGunma University Graduate School of MedicineMaebashiJapan

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-1333-8
  • Copyright Information Springer Science+Business Media Dordrecht 2013
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-1332-1
  • Online ISBN 978-94-007-1333-8
  • About this book
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