Table of contents

  1. Herbert Tempfer, Christine Lehner, Moritz Grütz, Renate Gehwolf, Andreas Traweger
  2. Andreas Clementi, Dominik Egger, Verena Charwat, Cornelia Kasper
  3. Gerjo J. V. M. van Osch, Andrea Barbero, Mats Brittberg, Diego Correa, Solvig Diederichs, Mary B. Goldring et al.
  4. Philip Lewis, Edina Silajdžić, Daniel R. Brison, Susan J. Kimber
  5. Irene Mencía Castaño, Rosanne M. Raftery, Caroline M. Curtin, Johannes Grillari, Heinz Redl, Fergal J. O’Brien
  6. Cedric Badowski, Aneesa Iskander, Diana Gaspar, Dimitrios I. Zeugolis, Michael Raghunath
  7. J. Jason Collier, Susan J. Burke
  8. Lucian Beer, Michael Mildner, Mariann Gyöngyösi, Hendrik Jan Ankersmit, Elisabeht Simader
  9. John T. Walker, Armand Keating, John E. Davies
  10. Elisabeth Kemter, Alexander Kind, Bruno Reichart, Eckhard Wolf

About this book


This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.


Adipose Derived Cells Biophysical Modulation Cell Differentiation Cell Tracking Olfactory Mucosa Primary Cells

Editors and affiliations

  • Jeffrey M. Gimble
    • 1
  • Darja Marolt
    • 2
  • Richard Oreffo
    • 3
  • Heinz Redl
    • 4
  • Susanne Wolbank
    • 5
  1. 1.Tulane Univ. Sch. of MedicineNew OrleansUSA
  2. 2.AUVA CenterLudwig Boltzmann Institute for ExperimenViennaAustria
  3. 3.Human Development and HealthUniversity of SouthamptonSouthamptonUK
  4. 4.Experimental and Clinical TraumatolLudwig Boltzmann Institute forWienAustria
  5. 5. AUVA CenterLudwig Boltzmann Institute for ExperimenViennaAustria

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Engineering
  • Online ISBN 978-3-319-37076-7
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