Table of contents

  1. Front Matter
    Pages i-x
  2. Neuro-Endocrine Immunoregulation

    1. D. L. Bellinger, C. L. Lubahn, A. B. Millar, J. L. Carter, S. Vyas, S. D. Perez et al.
      Pages 61-81
    2. M.-B. Niemi, G. Pacheco-López, H. Engler, C. Riether, R. Doenlen, M. Schedlowski
      Pages 123-150
  3. The Brain's Immune System

    1. M. T. Rinaudo, M. Piccinini
      Pages 223-234
    2. W. Stenzel, G. Alber
      Pages 235-262
    3. P. R. Lowenstein, K. Kroeger, C. Barcia, J. Zirger, D. Larocque, M. G. Castro
      Pages 263-281
    4. G. Juhász
      Pages 293-307
    5. S. Pawate, N. R. Bhat
      Pages 309-330
  4. Neuro Immune Mechanisms ofBrain Diseases

    1. C. J. Welsh, C. R. Young
      Pages 333-353
    2. B. Gran, K. O'Brien, D. Fitzgerald, A. Rostami
      Pages 355-377
    3. C. C. Ferrari, F. J. Pitossi
      Pages 395-406
    4. B. Giunta, F. Fernandez, J. Tan
      Pages 407-426

About this book


This volume contains data on multiple immunomodulators, many of which are also the products of hypothalamic brain cell neurosecretion. Interleukins (IL-1a, IL-1ß, IL-2, IL-4, IL-6, TNFa), immunophylin and ubiquitin as well as proline rich peptides, comprised of 10-15 amino acids are being produced in N. Supraopticus and N. Paraventricularis and then secreted into neurohypophysis. Along the neurosecretion of the mentioned cytokines, there are other immunomodulators, the primary structure of which had been completely deciphered such as: Immunophyllins, intracellular receptors of immunosuppressors FK506, cyclosporine A., rapamicin. They are peptidyl-prolyl-cis-trans-isomerases. There are novel immunological hypothalamic factors such as ubiquitin, macrophage migration inhibitory factor (MIF), as well as Thymosin ß 4(1-39). This data allowed us to propose the concept of neuroendocrine immune system of the brain.

Editors and affiliations

  • Abel Lajtha
    • 1
  • Armen Galoyan
    • 2
  • Hugo O. Besedovsky
    • 3
  1. 1.Center for NeurochemistryNathan S. Kline Institute for Psychiatric ResearchNew YorkUSA
  2. 2.The Buniatian Institute of Biochemistry the National Academy of SciencesYerevanRepublic of Armenia
  3. 3.Dept. Immunophysiology Medical FacultyInst. of Normal and Pathological PhysiologyMarburgGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 2008
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-387-30358-1
  • Online ISBN 978-0-387-30398-7
  • About this book
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