Table of contents

  1. Front Matter
    Pages i-lxii
  2. Introduction to Glycoscience

    1. Front Matter
      Pages 1-1
    2. Richard D. Cummings
      Pages 3-9
    3. Chi-Huey Wong, Naoyuki Taniguchi
      Pages 11-14
  3. Analytical and Structural Approach: Technical Description for Analyzing Glycans

    1. Front Matter
      Pages 15-15
    2. Koichi Honke, Norihiro Kotani
      Pages 17-23
    3. Yan Liu, Robert A. Childs, Ten Feizi
      Pages 25-34
    4. Chung-Yi Wu, Chi-Huey Wong
      Pages 35-43
    5. Chung-Yi Wu, Chi-Huey Wong
      Pages 45-52
    6. Stuart M. Haslam, Poh-Choo Pang, Aristotelis Antonopoulos, Anne Dell
      Pages 69-77
    7. Akihiko Kameyama, Yu-ki Matsuno
      Pages 94-101
    8. Kazuki Nakajima, Naoyuki Taniguchi
      Pages 103-110

About this book

Introduction

The aim of the book is to provide a succinct overview of the current status of glycoscience from both basic biological and medical points of view and to propose future directions, in order to facilitate further integrations of glycoscience with other fields in biological and medical studies.

Glycans (carbohydrate oligomers) are the so-called “building blocks” of carbohydrates, nucleic acids, proteins and lipids and play major roles in many biological phenomena as well as in various pathophysiological processes. However, this area of glycoscience has been neglected from the research community because glycan structures are very complex and functionally diverse and as compared to proteins and nucleic acids simple tools for the amplification, sequencing and auto-synthesis of glycans are not available. Many scientists in other fields of research have now realized that glycosylation, i.e. the addition of glycans to a protein backbone, is the most abundant post translational modification reactions and is an important field of research and sometimes they require a glycobiology and/or glycochemistry approach to be used. It is still difficult, however, for non-expert researchers to use these techniques. This book provides numerous but simple overviews of current topics and protocols for the experiments. The book is aimed at university students and above, including non-experts in the field of glycoscience.

Keywords

Chemical glycobiology Glyco-biomarkers Glycoimmunology Glyconeurology Systems glycobiology

Editors and affiliations

  • Naoyuki Taniguchi
    • 1
  • Tamao Endo
    • 2
  • Gerald W. Hart
    • 3
  • Peter H. Seeberger
    • 4
  • Chi-Huey Wong
    • 5
  1. 1.Systems Glycobiology Research GroupRIKEN-Max Planck Joint Research Center for Systems Chemical BiologyWakoJapan
  2. 2.Tokyo Metropolitan Institute of GerontologyTokyo Metropolitan Geriatric Hospital and Institute of GerontologyTokyoJapan
  3. 3.Department of Biological ChemistryJohns Hopkins University School of MedicineBaltimoreUSA
  4. 4.Department of Biomolecular SystemsMax-Planck-Institute of Colloids and InterfacesPotsdamGermany
  5. 5.Academica SinicaNanKangTaiwan

Bibliographic information

  • DOI https://doi.org/10.1007/978-4-431-54841-6
  • Copyright Information Springer Japan 2015
  • Publisher Name Springer, Tokyo
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-4-431-54840-9
  • Online ISBN 978-4-431-54841-6
  • About this book
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