Table of contents

  1. Front Matter
    Pages 1-27
  2. The “Modus Operandi” of Regulatory Toxicology

    1. Front Matter
      Pages 1-2
    2. Michael Schwenk, H. Paul A. Illing
      Pages 21-30
    3. Dietrich Henschler, Wolfgang Dekant
      Pages 49-55
    4. Werner Lilienblum, Stephen Harston
      Pages 57-63
    5. Maged Younes
      Pages 65-71
  3. Approaches Used

    1. Front Matter
      Pages 73-74
    2. Karl Georg Heimann, Kevin Doughty
      Pages 81-88
    3. Wolfgang Kaufmann, Matt C. Jacobsen
      Pages 89-98
    4. Eckhard von Keutz
      Pages 107-113
    5. Thomas Steger-Hartmann, Scott Boyer
      Pages 123-131
    6. Gert Ulrich Kuerzel, Christine Mauriac
      Pages 133-139
    7. Jürgen Pauluhn
      Pages 141-160
    8. Dieter Schrenk
      Pages 161-172
    9. Heidrun Ellinger-Ziegelbauer, Hans-Juergen Ahr
      Pages 173-179

About this book


This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004.  Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference.


environmental and occupational health exposure analysis regulatory toxicology risk assessment risk management and communication toxicological test procedures

Editors and affiliations

  • Franz-Xaver Reichl
    • 1
  • Michael Schwenk
    • 2
  1. 1.Walther-Straub-Institute of Pharmacology and ToxicologyLMU MunichMunichGermany
  2. 2.Formerly Medical SchoolHannoverGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-35373-4
  • Online ISBN 978-3-642-35374-1
  • About this book
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