Polyendocrine Disorders and Endocrine Neoplastic Syndromes

  • Annamaria Colao
  • Marie-Lise Jaffrain-Rea
  • Albert Beckers


  • Provides readers with comprehensive insights into the diagnosis and treatment of polyendocrine disorders and endocrine neoplastic syndromes

  • Written by international experts in the field

  • Auto-immune endocrine diseases are also discussed

Living reference work

Part of the Endocrinology book series (ENDOCR)

Table of contents

  1. Isabella Lupi, Alessandro Brancatella, Patrizio Caturegli
  2. Corrado Betterle, Chiara Sabbadin, Carla Scaroni, Fabio Presotto
  3. Filippo Ceccato, Gianluca Occhi
  4. Rosario Pivonello, Chiara Simeoli, Rosario Ferrigno, Maria Cristina De Martino, Davide Menafra, Cristina De Angelis et al.
  5. Improda Nicola, Salerno Mariacarolina, Capalbo Donatella
  6. Liliya Rostomyan, Iulia Potorac, Adrian F. Daly, Albert Beckers
  7. Francesca Marini, Francesca Giusti, Maria Luisa Brandi
  8. Sylvie Salenave, Philippe Chanson
  9. Roberta Centello, Antongiulio Faggiano, Elisa Giannetta
  10. Pauline Romanet, Pierre Goudet, Anne Barlier
  11. Pauline Delannoy, Iulia Potorac, Albert Beckers
  12. Vincent Rohmer, Delphine Prunier-Mirebeau, Iulia Potorac
  13. Ninelia Minaskan Karabid, Natalia S. Pellegata
  14. Giuseppe Opocher, Alfonso Massimiliano Ferrara, Stefania Zovato, Giovanni Barbon, Elisa Taschin, Francesca Schiavi
  15. Federica Guaraldi, Sofia Asioli, Valentino Marino Picciola, Diego Mazzatenta, Giovanni Corona

About this book


This comprehensive reference book is meant to support clinicians in the diagnosis and treatment of polyendocrine diseases and endocrine neoplastic syndromes.

Although a large majority of endocrine diseases present as sporadic cases, an increasing proportion can be identified as part of a polyendocrine or systemic syndrome. These include autoimmune endocrine diseases, which may be part of autoimmune polyendocrine disorders (APS) or rare complex disorders such as POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) or IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) syndromes.  On the other hand, endocrine tumors may develop in a variety of clinical conditions, including multiple endocrine neoplasia (MEN) syndromes, syndromic diseases such as McCune Albright or Carney’s complex, or peculiar familial associations  such as pheochromocytoma/paraganglioma syndromes.

The book discusses the significant advances that have been made in the clinical and genetic characterization of such entities, with major implications in terms of diagnosis and clinical management, including familial screening, as well as in terms of multidisciplinarity.

This volume is intended for clinicians, residents, specialists and physicians involved in the diagnosis and treatment of affected patients, including specialists in endocrinology, internal medicine, oncology and genetics.  


Autoimmune polyendocrine syndromes Multiple Endocrine Neoplasia MEN Syndromic diseases Genetics Familial screening

Editors and affiliations

  • Annamaria Colao
    • 1
  • Marie-Lise Jaffrain-Rea
    • 2
  • Albert Beckers
    • 3
  1. 1.Neuroendocrine UnitUniversity of Naples Federico II Neuroendocrine UnitNaplesItaly
  2. 2.Department of Biotechnological and Applied Clinical SciencesUniversity of L'Aquila and Neuroendocrinology, Neuromed IRCCSL'AquilaItaly
  3. 3.Department of EndocrinologyCentre Hospitalier Universitaire de Lièg Department of EndocrinologyLiègeBelgium

About the editors

Annamaria Colao is a professor at “Federico II” University of Naples and chief of the Neuroendocrine Unit, University Federico II, Naples, Italy. Her current areas of research include the molecular basis and clinical treatment of neuroendocrine tumors and tumors in the hypothalamus/pituitary region, the consequences of deficiency and excess of GH and IGF-I for the cardiovascular system, endocrine consequences in survivors of malignant neoplasia, and insulin resistance and cancer. Dr. Colao is a member of numerous medical societies, including the Italian Society of Endocrinology, the European Neuroendocrine Association, and the European Society of Endocrinology. She is the author of more than 500 peer-reviewed publications.

Marie-Lise Jaffrain-Rea is an assistant professor at the University of L’Aquila and head of the Neuroendocrinology service at the Neuromed Institute in Pozzilli, Italy. She is also an invited professor at the University of Liège, Belgium

. Her main areas of research are pituitary diseases and tumors of the sellar region, the pathogenesis and genetic basis of pituitary adenomas and their impact on familial screening and pharmacological treatment, as well as systemic complications of pituitary hormone hypersecretion. She is a member of the Italian Society of Endocrinology, the European Neuroendocrine Association and the European Society of Endocrinology. She is the author or co-author of 80 peer-reviewed publications and book chapters and over 200 communications at national and international scientific meetings.

Albert Beckers is a professor at the University of Liège and chief of the Department of Endocrinology at the University Hospital Centre, Liège and Belgium. His research areas include pituitary tumors, thyroid disease, genetic causes of endocrine cancers and rare inherited syndromes, with a special interest in the genetics of acromegaly and gigantism and their clinical implications.&nb

sp; He is a member of numerous medical societies, including the Belgian Endocrine Society, the European Neuroendocrine Association, and the European Society of Endocrinology and was awarded the 2016 Geoffrey Harris Prize of the European Society of Endocrinology. He has taken a particular interest in endocrine education, authoring a series of digital projects on aspects of pituitary disease. He is the author or co-author of more than 250 peer-reviewed publications and over 40 books and book chapters.

Bibliographic information

  • Book Title Polyendocrine Disorders and Endocrine Neoplastic Syndromes
  • Editors Annamaria Colao
    Marie-Lise Jaffrain-Rea
    Albert Beckers
  • Series Title Endocrinology
  • Series Abbreviated Title Endocrinology
  • DOI
  • Publisher Name Springer, Cham
  • eBook Packages Springer Reference Medicine Reference Module Medicine
  • eBook ISBN 978-3-319-73082-0
  • Series ISSN 2510-1927
  • Series E-ISSN 2510-1935
  • Edition Number 0
  • Number of Pages X, 390
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Endocrinology
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