Handbook of Immunosenescence

Basic Understanding and Clinical Implications

  • Tamas Fulop
  • Claudio Franceschi
  • Katsuiku Hirokawa
  • Graham Pawelec
Living reference work

Table of contents

  1. Claire E. Gustafson, David L. Lamar, Cornelia M. Weyand, Jörg J. Goronzy
  2. Beatriz Sánchez-Correa, Carmen Campos, Alejandra Pera, Juan M. Bergua, Esther Duran, Rafael Solana et al.
  3. Wan Wang, Feng Qian, Ruth R. Montgomery
  4. Masanori Utsuyama, Yuko Yoshida-Kikuchi, Masanobu Kitagawa, Katsuiku Hirokawa
  5. Devin M. Boe, Michael M. Chen, Elizabeth J. Kovacs
  6. Christine Bourgeois, Delphine Sauce
  7. Vu Luan Dang Chi, Catherine Sibille, Karen Willard-Gallo, Dominique Bron
  8. Austin B. Bigley, Forrest L. Baker, Guillaume Spielmann, R. J. Simpson
  9. Kouhei Yamamoto, Morito Kurata, Masanobu Kitagawa, Katsuiku Hirokawa
  10. Charles G. Rickert, James F. Markmann
  11. B. Henderson, A. Rossmann, G. Cappellano, B. Jakic, M. Buszko, Ch. Mayerl et al.
  12. Fernando Macian
  13. Jean L. Scholz, Yi Hao, William J. Quinn III, Michael P. Cancro
  14. Matteo Bulati, Calogero Caruso, Giuseppina Colonna-Romano
  15. Jacob E. Kohlmeier, Kenneth H. Ely, Lisa M. Connor, Alan D. Roberts, Eric J. Yager, David L. Woodland et al.
  16. Mauro Provinciali, Elisa Pierpaoli, Marco Malavolta, Alessia Donnini, Arianna Smorlesi, Cristina Gatti
  17. Lara Gibellini, Marcello Pinti, Sara De Biasi, Elena Bianchini, Simone Pecorini, Anna De Gaetano et al.
  18. Rebeca Alonso-Arias, Raquel Marcos-Fernández, María Iglesias-Escudero, Marco A. Moro-García
  19. Graham Pawelec, Jürgen Kempf, Anis Larbi, Yvonne Barnett
  20. George C. Wang, Yen-Ling Chiu, Jeremy D. Walston
  21. Susan E. McNerlan, Owen A. Ross, I. Maeve Rea
  22. Owen A. Ross, Ronald Walton, Kelly M. Hinkle, Neill Graff-Radford, I. Maeve Rea
  23. Silvia Della Bella
  24. Anis Larbi, Emilie Combet Aspray, Graham Pawelec, Abdelouahed Khalil, Tamas Fulop
  25. Helen R. Griffiths, Golam Yahia
  26. Hui-Chen Hsu, Jian Chen, John D. Mountz
  27. Christine Bäuerl, Marta Selma-Royo, Ana Gabriela Mera-Balseca, Maria Carmen Collado, Gaspar Perez-Martinez
  28. Victor Appay, Delphine Sauce, Anthony D. Kelleher
  29. Laura A. Vogel, Sarah Palackdharry, Laura M. Zimmerman, Rachel M. Bowden
  30. Pascale Baden, Silvia De Cicco, Cong Yu, Michela Deleidi
  31. Katharina Kerschan-Schindl, Elena Nebot Valenzuela, Peter Pietschmann

About this book


“Immunosenescence” is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. Indeed, during the almost 10 years that have passed since the first edition of this Handbook, a wealth of additional information has emerged from animal models and also from increasingly available human data. Numerous new aspects of the immune changes with aging have emerged, while others became less prominent. The application of the new multi-“omics” techniques in immunology have revolutionized our molecular understanding of basic immune mechanisms. The extended and revisited concept of Inflamm-aging sheds a new light on the intricate relationships among immunosenescence and inflamm-aging. The new concept of inflamm-aging integrates different emerging experimental data such as those pertaining to the senescence-associated secretory phenotype and responses to damage. “Geroscience” is emphasising the role of immune changes during life in all manner of age-related chronic diseases such as cancer and neurodegenerative disorders. The field is poised to be in a position to translate these accumulated data into the clinical setting via a better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This new edition of the Handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in both basic research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, microbiome, lipids, vaccination and the burning question “can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?”


Immunosenescence Immunity T-cells Aging Age-associated pathologies Gerontology Inflamm-aging

Editors and affiliations

  • Tamas Fulop
    • 1
  • Claudio Franceschi
    • 2
  • Katsuiku Hirokawa
    • 3
  • Graham Pawelec
    • 4
  1. 1.Division of Geriatrics Research Center on AgingUniversity of Sherbrooke Dept. of MedicineSherbrookeCanada
  2. 2.Dept of Experimental PathologyUniversity of BolognaBolognaItaly
  3. 3.Institute for Health and Life SciencesTokyoJapan
  4. 4.Center for Medical ResearchUniversity of TübingenTübingenGermany

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Reference Module Biomedical and Life Sciences
  • Online ISBN 978-3-319-64597-1
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