Table of contents

  1. Front Matter
    Pages i-xv
  2. W. P. T. James
    Pages 1-30
  3. Antonio Giordano, Enzo Nisoli
    Pages 31-50
  4. Saverio Cinti
    Pages 51-74
  5. Lidia Castagneto Gissey, James Casella Mariolo, Geltrude Mingrone
    Pages 75-88
  6. Roberto Vettor, Scilla Conci
    Pages 89-108
  7. Gemma Xifra, José Maria Moreno-Navarrete, José Manuel Fernández-Real
    Pages 109-126
  8. Massimo Cuzzolaro
    Pages 127-150
  9. James D. Crane, Barbara M. McGowan
    Pages 151-177
  10. Paul Cordero, Jiawei Li, Jude A. Oben
    Pages 179-194
  11. Sviatlana Zhyzhneuskaya, Roy Taylor
    Pages 195-226
  12. Vasilios Kotsis, Christina Antza, Giannis Doundoulakis, Stella Stabouli
    Pages 227-241
  13. Ian W. Seetho, John P. H. Wilding
    Pages 243-271
  14. Lyn D. Ferguson, Naveed Sattar
    Pages 273-293
  15. Claudia K. Fox, Justin R. Ryder, Amy C. Gross, Aaron S. Kelly
    Pages 295-322
  16. R. Drew Sayer, James O. Hill
    Pages 323-348
  17. Vanessa Snowdon-Carr
    Pages 349-371
  18. Phong Ching Lee, John B. Dixon
    Pages 373-399
  19. Donna H. Ryan, Sarah R. Yockey
    Pages 401-424
  20. Werd Al-Najim, Carel W. le Roux
    Pages 425-434

About this book


This book presents the latest advances in our understanding of the pathophysiologic basis that induces the chronic positive energy balance necessary to progressively store excessive amounts of fat mass. It highlights the clinical complications of obesity, while also focusing on the major scientific advances that have highlighted the role of genetics, adipose tissue endocrinology and the environment in the mechanisms and causes of obesity. Particular attention is given to the consequences of obesity, including an ever -increasing number of other diseases such as type 2 diabetes, cardiovascular diseases and cancer, as well as conditions such as arthropathy, asthma, non-alcoholic liver disease, and dementia. Increasingly recognized uniting causes highlight the role of systemic, local and paracrine actions of adipocytokines in causing inflammation. As we come to better understand how hypothalamic control of energy balance is influenced by endocrine signaling from the gut and adipose tissue, it paves the way for new therapeutic targets and a resurgence of pharmacological and surgical approaches to treatment. 

Written by respected experts in the field, this volume is intended as a major reference source for endocrinologists, nutritionists, basic and clinical scientists alike.


Neuroendocrinology of energy balance Adipose organ Eating disorders Dietary treatment Pharmacological approaches Surgical approaches

Editors and affiliations

  • Paolo Sbraccia
    • 1
  • Nicholas Finer
    • 2
  1. 1.Department of Systems Medicine, Internal Medicine Unit and Obesity CenterUniversity of Rome Tor Vergata, University Hospital Policlinico Tor VergataRomeItaly
  2. 2.National Centre for Cardiovascular PreventionUniversity College LondonLondonUK

About the editors

Paolo Sbraccia is Full Professor of Internal Medicine in the Department of Systems Medicine of the University of Rome "Tor Vergata", Chief of the Internal Medicine Unit and Obesity Center (EASO accredited Collaborating Centre for Obesity Management) at the University Hospital Policlinico Tor Vergata, Director of the Specialization School in Internal Medicine, and Chairman of the Undergraduate Course in Dietetics.

Prof. Sbraccia is also currently serving as President of the Italian Federation of Endocrinology, Diabetology, Andrology, Metabolism and Obesity and as Vice President of the Italian Barometer Diabetes Observatory. In addition, he is Past President of the Italian Society of Obesity and a member of the European Medicines Agency’s Scientific Advisory Group on Diabetes/Endocrinology.

In 2011, on behalf of SIO, he coordinated the Steering Committee for the Italian Guidelines for the Management of Obesity, and in 2016 he was Editor of the book “Clinical Management of Overweight and Obesity, Recommendations of the Italian Society of Obesity (SIO)”.

Professor Sbraccia is also a member of the editorial boards and reviewer panels of various scientific journals; he was recently Editor of the book “Clinical Management of Overweight and Obesity, Recommendations of the Italian Society of Obesity (SIO)” and coordinated an SIO steering committee for the Italian Guidelines for the Management of Obesity.

Nick Finer has been since 2016 Senior Principal Clinical Scientist with Novo Nordisk, Global Medical Affairs. He is also Honorary Clinical Professor in the National Centre for Cardiovascular Prevention and Outcomes within the Institute of Cardiovascular Science at University College London. Qualifying in Biochemistry and Medicine at University College London, Finer has held senior clinical and academic appointments as an Endocrinologist, Obesity and Internal Medicine Physician at UMDS Guy’s and St Thomas’ Hospitals, Luton and Dunstable Hospitals NHS Trust, University of Cambridge and University College Hospital London. Nick Finer is an elected Fellow of the US Obesity Society, and of the UK Association for Nutrition; in 2013 he received the Bisset Hawkins Medal 'for work in advancing sanitary science or in promoting public health' awarded by the Royal College of Physicians. Finer chaired World Obesity - Clinical Care until 2015, developing the SCOPE educational programme. He is past-chair of the UK Association for the Study of Obesity. Finer co-authored the Royal College of Physicians report ‘Action on obesity: comprehensive care for all’, was a member of the UK Government Advisory Group on Obesity, the Clinical Reference Group that advised NHS England on commissioning of specialist obesity services, and the NICE Public Health Advisory Group. Finer is editor-in-chief of Clinical Obesity and has published (more than 200 peer reviewed papers) and lectured extensively on obesity and its complications as an internationally invited speaker.

Bibliographic information

  • Book Title Obesity
  • Book Subtitle Pathogenesis, Diagnosis, and Treatment
  • Editors Paolo Sbraccia
    Nicholas Finer
  • Series Title Endocrinology
  • Series Abbreviated Title Endocrinology
  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Reference Module Medicine
  • Hardcover ISBN 978-3-319-46932-4
  • eBook ISBN 978-3-319-46933-1
  • Series ISSN 2510-1927
  • Series E-ISSN 2510-1935
  • Edition Number 1
  • Number of Pages XV, 440
  • Number of Illustrations 17 b/w illustrations, 49 illustrations in colour
  • Topics Endocrinology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology