Table of contents

  1. Front Matter
    Pages i-xix
  2. Michele Farisco, Carlo Petrini
    Pages 7-39
  3. Andrew S. Hoffman, Alberto Cambrosio, Renaldo Battista
    Pages 57-93
  4. Craig Mitton, Stuart Peacock
    Pages 95-103
  5. Huseyin Naci, Eldon Spackman
    Pages 105-121
  6. Michael A. Fischer
    Pages 123-133
  7. Patrícia Coelho de Soárez, Marcos Bosi Ferraz
    Pages 149-159
  8. Kathleen W. Wyrwich
    Pages 161-179
  9. Ann C. Bonham, Mildred Z. Solomon, Brian Mittman, Alexander K. Ommaya, Anne Berlin
    Pages 181-203
  10. Stirling Bryan, Marthe Gold
    Pages 205-216
  11. Oriana Ciani, Rosanna Tarricone, Rod S. Taylor
    Pages 275-290

About this book


The second volume in the Health Services Research series provides a series of perspectives on comparative effectiveness research. Motivated by concern from the general public, governments in virtually all countries with developed and rapidly developing economies have been actively seeking and promoting ways of improving the patient experience of health care, improving the health of populations, and reducing the per capita cost of health care. While comparing treatment outcomes is not a new concept, appreciation of its potential application has grown in recent years. In addition to traditional health sciences methods, modern approaches to comparative effectiveness research now include greater emphasis on social sciences frameworks such as economics, ethics, and implementation science. Moreover, a key feature of the modern approach to comparing treatment outcomes is a focus on the individual patient through explicit consideration of inter-patient variability and patient-reported outcomes.  

Comparative Effectiveness Research presents a series of chapters of relevance including introductions to areas that are being incorporated when comparing treatments, country-specific applications, patient-centred approaches, and modern methods. Included are chapters on the following areas that are being considered in treatment comparisons: ethics, economics and costs, implementation science, modern payment schemes (coverage with evidence development), and priority setting. Country-specific examples include an overview chapter on national approaches from various countries in Europe, Australia, and Canada, as well as specific chapters on comparative effectiveness research in Brazil and in the United States. The focus on the individual patient is described through chapters on patient-centred comparative effectiveness research, individualized treatment, the link with personalized medicine, and incorporating patient and public input for treatment. Methodological chapters include overviews of data sources, study designs, new statistical methods of combining results, the link with evidence-based medicine, specific issues when comparing drug and non-drug technologies, and dissemination of results.


Access to care Comparative effectiveness Economic evaluation Health care quality Health care systems

Editors and affiliations

  • Adrian Levy
    • 1
  • Boris Sobolev
    • 2
  1. 1.Dalhousie UniversityCommunity Health & EpidemiologyHalifaxCanada
  2. 2.School of Population and Public HealthUniversity of British ColumbiaVancouverCanada

About the editors

Boris Sobolev, MSc, PhD, is a senior scientist at the Center for Clinical Epidemiology and Evaluation and a faculty member at the University of British Columbia (UBC) School of Population and Public Health in Vancouver, Canada. Since 2003, he is a Canada Research Chair in Statistics and Modeling for Health Care. In 2004-2005, Prof. Sobolev was a Peter Wall Early Career Scholar, and currently he is a Faculty Associate at the UBC Peter Wall Institute for Advanced Studies serving on its Adjudication Committee.

Adrian Levy, PhD, is professor of epidemiology and health services research working at Dalhousie University in Halifax, Nova Scotia, Canada. He commenced his academic career working for the Quebec Council for Health Technology Assessment doing applied health research on real world use of health technologies. Dr. Levy is also the nominated principal investigator for the Maritime Strategy for Patient Oriented Research SUPPORT Unit. This initiative, co-funded by the Canadian Institutes of Health Research, offers research infrastructure designed to promote patient-centred outcomes and health services research in Canada’s three Maritime provinces. The central goals include advancing research on health systems, knowledge translation and implementation of healthcare transformation, and implementing research at the point of care. 

Bibliographic information

Industry Sectors
Health & Hospitals
Public Health


“The book … presents perspectives on CER across 356 pages and 20 chapters and best serves as a reference book for individuals seeking standalone essays that discuss various aspects of CER. … the book provides a comprehensive collection of topics that are relevant for students and professionals wishing to understand CER. … Comparative Effectiveness Research in Health Services provides a solid foundation for learning a significant amount about one of the most important methodologies in health care decision making today.” (Jonathan M. Tan, Jack O. Wasey and Allan F. Simpao, Anestesia & Analgesia, Vol. 125 (6), December, 2017)