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© 2002

Drug Discovery and Evaluation

Pharmacological Assays Second Completely Revised, Updated, and Enlarged Edition

  • H. Gerhard Vogel
  • Wolfgang H. Vogel
  • Bernward A. Schölkens
  • Jürgen Sandow
  • Günter Müller
  • Wolfgang F. Vogel
Reference work

Table of contents

  1. Front Matter
  2. H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller, Wolfgang F. Vogel
    Pages 1-20
  3. H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller, Wolfgang F. Vogel
    Pages 26-276
  4. H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller, Wolfgang F. Vogel
    Pages 277-309
  5. H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller, Wolfgang F. Vogel
    Pages 317-348
  6. H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller, Wolfgang F. Vogel
    Pages 351-383
  7. H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller, Wolfgang F. Vogel
    Pages 385-593
  8. H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller, Wolfgang F. Vogel
    Pages 595-643
  9. H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller, Wolfgang F. Vogel
    Pages 645-668
  10. H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller, Wolfgang F. Vogel
    Pages 670-773
  11. H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller, Wolfgang F. Vogel
    Pages 775-820
  12. H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller, Wolfgang F. Vogel
    Pages 827-945
  13. H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller, Wolfgang F. Vogel
    Pages 948-1051
  14. H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller, Wolfgang F. Vogel
    Pages 1053-1092
  15. H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller, Wolfgang F. Vogel
    Pages 1095-1124
  16. H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller, Wolfgang F. Vogel
    Pages 1130-1294
  17. H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller, Wolfgang F. Vogel
    Pages 1295-1308
  18. H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller, Wolfgang F. Vogel
    Pages 1312-1368
  19. H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller, Wolfgang F. Vogel
    Pages 1369-1382
  20. Back Matter

About this book

Introduction

Now expanded and updated to include molecular biology and genetic engineering techniques! The 2nd edition of this successful reference book contains a comprehensive selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic respiratory, renal and immunomodulatory activities. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. The enclosed and fully searchable CD-ROM allows easy identification of specific tests. An appendix with up-to-date guidelines and legal regulations for animal experiments in various countries will help the reader to plan experiments more effectively.

Keywords

Arzneimittel Arzneimittelwirkungen Pharmakologie Toxikologie Wirkstoffe Wirkstoffforschung assays drug action drugs pharmacological tests toxicology Arzneimittelwirkung biology drug drug discovery molecular biology pharmaceutical pharmacology research

Editors and affiliations

  • H. Gerhard Vogel
    • 1
  • Wolfgang H. Vogel
    • 2
  • Bernward A. Schölkens
    • 3
  • Jürgen Sandow
    • 3
  • Günter Müller
    • 4
  • Wolfgang F. Vogel
    • 5
  1. 1.Johann Wolfgang Goethe-UniversitätFrankfurtGermany
  2. 2.Department of PharmacologyJefferson Medical College, Thomas Jefferson UniversityPhiladelphiaUSA
  3. 3.Aventis Deutschland GmbHJohann Wolfgang Goethe-Universität FrankfurtFrankfurtGermany
  4. 4.Institut für Genetik, Avenfis Deutschland GmbHLudwig Maximilian-Universität MünchenMünchenGermany
  5. 5.Department of Laboratory Medicine and Pathobiology, Faculty of MedicineUniversity of TorontoTorontoCanada

Bibliographic information

  • Book Title Drug Discovery and Evaluation
  • Book Subtitle Pharmacological Assays Second Completely Revised, Updated, and Enlarged Edition
  • Editors Hans G. Vogel
  • DOI https://doi.org/10.1007/3-540-29837-1
  • Copyright Information Springer-Verlag Berlin Heidelberg 2002
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-33360-9
  • eBook ISBN 978-3-540-29837-3
  • Edition Number 2
  • Number of Pages XLIV, 1408
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Pharmacology/Toxicology
    Pharmacy
    Biochemistry, general
  • Buy this book on publisher's site
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Reviews

From the reviews of the second edition:

"Pharmacological studies are a pivotal but sometimes neglected area … . Failure to evaluate your candidate compound in appropriate models will greatly reduce your chances of success … . This excellent reference book will assist you in avoiding this fate. … Although the update has increased the book from around 750 to 1400 pages, it is still indexed in a clear, concise way making access to each assay easy. … I would thoroughly recommend this book. … it is a well-worth, long term investment." (Paul Baldrick, British Toxicology Society Newsletter, Issue 20, 2002)

"The second edition of ‘Drug Discovery and Evaluation’ presents an expanded and updated version of one of the classic reference handbooks on pharmacological assays. … Each assay description is sufficiently outlined and equipped with outstanding literature references. … A newly included CD-ROM provides easy identification of tests, guidelines and even legal regulations for animal experiments. … This comprehensive classical reference handbook mainly addresses the needs of pharmacological institutes and research groups working in this area." (Dr. Jürg Gertsch, BioWorld, Issue 2, 2003)