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“Chip”ping Away at Heart Failure

  • Protocol
Congenital Heart Disease

Part of the book series: Methods in Molecular Medicine ((MIMM,volume 126))

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Abstract

Studies in the field of microarray technology have exploded onto the scene to delve into the unknown underlying mechanisms and pathways in molecular disease. Diseases of the cardio-vascular system, particularly those with unexplained molecular etiologies, such as heart failure, have more recently been investigated using array technology. Our laboratory has sought to examine gene expression profiles of human heart failure using a 10,000+ element cardio-vascular-based complementary DNA microarray constructed in-house, termed the “CardioChip.” Our studies have identified panels of genes, such as those encoding sarcomeric and cytoskeletal proteins, stress proteins, and Ca2+ regulators, that are differentially expressed in disease conditions as compared with samples from nonfailing hearts. Microarrays are effective tools for examining molecular portraits of the cardiovascular disease condition.

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Author information

Authors and Affiliations

  1. Department of Medicine, Brigham and Women’s Hospital, Boston, MA

    J. David Barrans & Choong-Chin Liew

Authors
  1. J. David Barrans
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  2. Choong-Chin Liew
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Editor information

Editors and Affiliations

  1. Transplantation Biology Research Lab Division of Cardiothoracic Surgery Children’s Hospital of Los Angeles, Los Angeles, CA, USA

    Mary Kearns-Jonker

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© 2006 Humana Press Inc.

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David Barrans, J., Liew, CC. (2006). “Chip”ping Away at Heart Failure. In: Kearns-Jonker, M. (eds) Congenital Heart Disease. Methods in Molecular Medicine, vol 126. Humana Press. https://doi.org/10.1385/1-59745-088-X:157

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  • DOI: https://doi.org/10.1385/1-59745-088-X:157

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-375-6

  • Online ISBN: 978-1-59745-088-1

  • eBook Packages: Springer Protocols

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