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Magnetic Resonance Imaging pp 365–386Cite as

Biological Applications of Manganese-Enhanced Magnetic Resonance Imaging

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Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 124))

Abstracts

The manganese ion (Mn2+) has long been used in biomedical research as an indicator of calcium (Ca2+) influx in conjunction with fluorescent microscopy because it is well established that Mn2+ enters cells through voltage-gated Ca2+ channels. Mn2+ is also paramagnetic, resulting in a shortening of the spin-lattice relaxation time constant, T1, which yields positive contrast enhancement in T1-weighted magnetic resonance imaging (MRI), specific to tissues in which the ion has accumulated. Manganese-enhanced MRI (MEMRI) uses a combination of these properties of Mn2+ to elucidate anatomical information and to identify regions of cellular activity. The focus of this chapter will detail some of the current MEMRI methodologies and biological applications.

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Author information

Authors and Affiliations

  1. Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX

    Robia G. Pautler

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  1. Robia G. Pautler
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Editor information

Editors and Affiliations

  1. Department of Radiology, Evanston Northwestern Healthcare, Evanston and Feinberg School of Medicine at Northwestern University, Chicago, IL

    Pottumarthi V. Prasad

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© 2006 Humana Press Inc.

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Pautler, R.G. (2006). Biological Applications of Manganese-Enhanced Magnetic Resonance Imaging. In: Prasad, P.V. (eds) Magnetic Resonance Imaging. Methods in Molecular Medicine™, vol 124. Humana Press. https://doi.org/10.1385/1-59745-010-3:365

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  • DOI: https://doi.org/10.1385/1-59745-010-3:365

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-397-8

  • Online ISBN: 978-1-59745-010-2

  • eBook Packages: Springer Protocols

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