Identification of Steroid Hormone-Regulated Genes in Breast Cancer

  • Bruce R. Westley
  • Felicity E. B. May
Part of the Methods in Molecular Medicine book series (MIMM, volume 120)


The measurement of the expression of hormonally regulated genes in breast cancer may provide an indication of its hormone responsiveness. In addition, these genes may provide novel therapeutic targets. This chapter reviews the hormonally responsive genes that have been identified in breast cancer cell lines and tumors, using differential hybridization, differential display, serial analysis of gene expression, and array technology. The biological relevance of the genes identified is discussed.

Key Words

Estrogen breast cancer gene expression SAGE regulation of gene expression microarray 


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Copyright information

© Humana Press Inc. 2006

Authors and Affiliations

  • Bruce R. Westley
    • 1
  • Felicity E. B. May
    • 2
  1. 1.Northern Institute for Cancer Research, Medical SchoolThe University of Newcastle upon TyneNewcastle upon TyneUK
  2. 2.Northern Institute for Cancer Research, Medical School, Framlington PlaceThe University of Newcastle upon TyneNewcastle upon TyneUK

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