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Scale-Up of Natural Product Isolation

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Natural Products Isolation

Part of the book series: Methods in Biotechnology ((MIBT,volume 20))

Summary

Scale-up of natural product isolation involves not only an increase in the scale of the purification of the target compound but also an improved level or scale in its production. As the scale increases, efficiency of operation becomes more important, necessitating process development. The nature of the scale-up challenge inevitably changes throughout the development cycle of a particular compound. This, together with the resources available, ultimately influences the strategy adopted. Factors important in successful scale-up are discussed with particular reference to microbial products and illustrated in case studies of the scale-up isolations of xenovulene A from Acremonium strictum, and (6S)-4,6-dimethyldodeca-2E,4E-dienoyl phomalactone from a Phomopsis sp.

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Author information

Authors and Affiliations

  1. Cubist Pharmaceuticals (UK) Ltd, Slough, Berkshire, UK

    Steven M. Martin & Stephen K. Wrigley

  2. Cubist Pharmaceuticals (UK) Ltd, Berkshire, UK

    David A. Kau

Authors
  1. Steven M. Martin
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  2. David A. Kau
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  3. Stephen K. Wrigley
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Editor information

Editors and Affiliations

  1. Pharmaceutical Biotechnology Research Group school of Biomedical Sciences, University of Ulster at Coleraine, Coleraine, Northern Ireland, UK

    Satyajit D. Sarker

  2. Molecular Nature Limited Plas Gogerddan, Aberystwyth, Wales, UK

    Zahid Latif

  3. Phytochemistry Research Lab Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow, Scotland, UK

    Alexander I. Gray

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© 2006 Humana Press Inc., Totowa,NJ

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Martin, S.M., Kau, D.A., Wrigley, S.K. (2006). Scale-Up of Natural Product Isolation. In: Sarker, S.D., Latif, Z., Gray, A.I. (eds) Natural Products Isolation. Methods in Biotechnology, vol 20. Humana Press. https://doi.org/10.1385/1-59259-955-9:439

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  • DOI: https://doi.org/10.1385/1-59259-955-9:439

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-447-0

  • Online ISBN: 978-1-59259-955-4

  • eBook Packages: Springer Protocols

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