Abstract
Increasing evidence suggests that non-sex-linked genetic factors play a role in determining both susceptibility to, and progression of, liver fibrosis. The elucidation of these factors will have many potential benefits in the management of patients with chronic liver disease. A variety of approaches can be used to look for genetic factors playing a role in liver fibrosis. In the future, genome-wide single nucleotide polymorphism (SNP) scanning of cases and controls may become feasible; however, to date, studies have relied on candidate-gene, case-control, allele-association methodology. This section will focus on the design and interpretation of case-control association studies in liver disease using non-alcoholic fatty liver disease (NAFLD) to illustrate the key issues and potential pitfalls of this approach.
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Day, C.P. (2005). Genetic Studies to Identify Hepatic Fibrosis Genes and SNPs in Human Populations. In: Varga, J., Brenner, D.A., Phan, S.H. (eds) Fibrosis Research. Methods in Molecular Medicine, vol 117. Humana Press. https://doi.org/10.1385/1-59259-940-0:315
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DOI: https://doi.org/10.1385/1-59259-940-0:315
Publisher Name: Humana Press
Print ISBN: 978-1-58829-479-1
Online ISBN: 978-1-59259-940-0
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