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Fibrosis Research pp 251–259Cite as

Animal Models of Pulmonary Fibrosis

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Part of the book series: Methods in Molecular Medicine ((MIMM,volume 117))

Abstract

In general, there are two types of animal models: natural and experimental. Because there are no natural models for pulmonary fibrosis, an experimental model that reproduces key aspects of the human disease would be useful for the study of this form of lung disease, the natural history of which is not always known. To date, a variety of animal models have been used to investigate mechanisms of pulmonary and other types of fibrosis, including the intratracheal instillation of bleomycin, fluorescein isothiocyanate, or particulate matter, such as silica and asbestos. This chapter will describe two commonly used techniques, namely bleomycin and silica-induced, which have been developed for the study of pulmonary fibrosis in animal models.

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Acknowledgments

This work was supported in part by the American Lung Association of Michigan (grant to MG-K) and by National Institutes of Health grants HL28737, HL31963, HL52285, and HL 77297 (to SHP).

Author information

Authors and Affiliations

  1. Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI

    Mehrnaz Gharaee-Kermani

  2. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI

    Matthew Ullenbruch & Sem H. Phan

Authors
  1. Mehrnaz Gharaee-Kermani
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  2. Matthew Ullenbruch
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  3. Sem H. Phan
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Editor information

Editors and Affiliations

  1. Feinberg School of Medicine, Northwestern University, Chicago, IL

    John Varga MD

  2. College of Physicians and Surgeons, Columbia University, New York, NY

    David A. Brenner MD

  3. University of Michigan Medical School, Ann Arbor, MI

    Sem H. Phan MD, PhD

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© 2005 Humana Press Inc.

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Gharaee-Kermani, M., Ullenbruch, M., Phan, S.H. (2005). Animal Models of Pulmonary Fibrosis. In: Varga, J., Brenner, D.A., Phan, S.H. (eds) Fibrosis Research. Methods in Molecular Medicine, vol 117. Humana Press. https://doi.org/10.1385/1-59259-940-0:251

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  • DOI: https://doi.org/10.1385/1-59259-940-0:251

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-479-1

  • Online ISBN: 978-1-59259-940-0

  • eBook Packages: Springer Protocols

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