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Dynamic In Vivo Imaging of Receptors in Small Animals Using Positron Emission Tomography

  • Protocol
Receptor Binding Techniques

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 306))

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Abstract

Positron emission tomography (PET) is a functional imaging technique that is used to study biological processes in vivo. Data obtained in a PET scan can provide information regarding tissue physiology or pathophysiology, as well as pharmacokinetic and pharmacodynamic information. It is the most sensitive technique available to image and quantify receptor distributions in vivo, and it has been used extensively to study major neurotransmitter systems such as the dopamine, serotonin, benzodiazepine, opiate, and cholinergic systems (1). Over the years, PET has increasingly been recognized as a very powerful tool to accelerate development and assessment of existing and novel drugs (6–7).

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Author information

Authors and Affiliations

  1. Department of Psychiatry, University of Cambridge, Cambridge, UK

    Peter Johnström

  2. Centre for Clinical Investigation, Addenbrooke’s Hospital, Cambridge, UK

    Peter Johnström

  3. Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK

    Tim D. Fryer

  4. Academic Neurosurgery Unit, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK

    Hugh K. Richards

  5. Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK

    Olivier Barret

  6. Clinical Pharmacology Unit, University of Cambridge, Cambridge, UK

    Anthony P. Davenport

  7. Centre for Clinical Investigation, Addenbrooke’s Hospital, Cambridge, UK

    Anthony P. Davenport

Authors
  1. Peter Johnström
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  2. Tim D. Fryer
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  3. Hugh K. Richards
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  4. Olivier Barret
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  5. Anthony P. Davenport
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Editor information

Editors and Affiliations

  1. Clinical Pharmacology Unit, University of Cambridge, Centre for Clinical Investigation, Addenbrooke7s Hospital, Cambridge, UK

    Anthony P. Davenport

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© 2005 Humana Press Inc.

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Johnström, P., Fryer, T.D., Richards, H.K., Barret, O., Davenport, A.P. (2005). Dynamic In Vivo Imaging of Receptors in Small Animals Using Positron Emission Tomography. In: Davenport, A.P. (eds) Receptor Binding Techniques. Methods in Molecular Biology™, vol 306. Humana Press. https://doi.org/10.1385/1-59259-927-3:217

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  • DOI: https://doi.org/10.1385/1-59259-927-3:217

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-420-3

  • Online ISBN: 978-1-59259-927-1

  • eBook Packages: Springer Protocols

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