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Measurement of Radioligand Binding by Scintillation Proximity Assay

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Receptor Binding Techniques

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 306))

Abstract

Scintillation proximity assay (SPA) is a homogeneous assay technology (1) which is bead-based and removes the need for a filtration step to separate bound from free ligand in a receptor-binding assay. The principle of the technology is shown in Fig. 1 .

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References

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Author information

Authors and Affiliations

  1. The Maynard Centre, GE Healthcare Biosciences, Cardiff, UK

    Jenny Berry & Molly Price-Jones

Authors
  1. Jenny Berry
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  2. Molly Price-Jones
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Editor information

Editors and Affiliations

  1. Clinical Pharmacology Unit, University of Cambridge, Centre for Clinical Investigation, Addenbrooke7s Hospital, Cambridge, UK

    Anthony P. Davenport

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© 2005 Humana Press Inc.

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Berry, J., Price-Jones, M. (2005). Measurement of Radioligand Binding by Scintillation Proximity Assay. In: Davenport, A.P. (eds) Receptor Binding Techniques. Methods in Molecular Biology™, vol 306. Humana Press. https://doi.org/10.1385/1-59259-927-3:121

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  • DOI: https://doi.org/10.1385/1-59259-927-3:121

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-420-3

  • Online ISBN: 978-1-59259-927-1

  • eBook Packages: Springer Protocols

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