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Surface-Functionalized Nanoparticles for Controlled Drug Delivery

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NanoBiotechnology Protocols

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 303))

Abstract

Nanoparticles have been extensively investigated in drug-delivery systems. Especially, the effectiveness of the surface-functionalized nanoparticles, which consist of copolymers with functional molecules, is well demonstrated. This chapter describes the complete technique for the preparation of surface-functionalized nanoparticles. Tetracycline with an affinity to bone was chosen as a model material for surface functionalization. There are two steps for the preparation of tetracycline-modified nanoparticles. The first step is the conjugation of poly(D,L-lactide-coglycolic acid) with tetracycline via carbodiimide chemistry and is the most often employed. Three kinds of techniques—the emulsification-diffusion method, nanoprecipitation, and the dialysis method—are used for nanoparticle formation of the resulting copolymer. Prepared nanoparticles having a size <200 nm and a hydrophilic surface layer can be applied for bone-specific drug delivery.

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Acknowledgments

We acknowledge the financial support of the Korea Institute of S&T Evaluation and Planning (National Research Laboratory Program, 2000-NNL-01-C-032).

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Authors and Affiliations

  1. Division of Chemical Engineering and Biotechnology, Yonsei University, Seoul, Korea

    Sung-Wook Choi & Woo-Sik Kim

  2. Nanosphere Process and Technology Laboratory, Yonsei University, Seoul, Korea

    Jung-Hyun Kim

Authors
  1. Sung-Wook Choi
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  2. Woo-Sik Kim
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  3. Jung-Hyun Kim
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Editor information

Editors and Affiliations

  1. The Department of Chemistry, Vanderbilt University, Nashville, TN

    Sandra J. Rosenthal  & David W. Wright  & 

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© 2005 Humana Press Inc.

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Choi, SW., Kim, WS., Kim, JH. (2005). Surface-Functionalized Nanoparticles for Controlled Drug Delivery. In: Rosenthal, S.J., Wright, D.W. (eds) NanoBiotechnology Protocols. Methods in Molecular Biology™, vol 303. Humana Press. https://doi.org/10.1385/1-59259-901-X:121

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  • DOI: https://doi.org/10.1385/1-59259-901-X:121

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-276-6

  • Online ISBN: 978-1-59259-901-1

  • eBook Packages: Springer Protocols

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