Probing DNA Structure With Nanoparticles

  • Rahina Mahtab
  • Catherine J. Murphy
Part of the Methods in Molecular Biology™ book series (MIMB, volume 303)


Semiconductor nanoparticles, also known as quantum dots, are receiving increasing attention for their biological applications. These nanomaterials are photoluminescent and are being developed both as dyes and as sensors. Here we describe our “sensor” use of quantum dots to detect different intrinsic DNA structures. Structural polymorphism in DNA may serve as a biological signal in vivo, highlighting the need for recognition of DNA structure in addition to DNA sequence in biotechnology assays.

Key Words

DNA oligonucleotides quantum dots semiconductor nanoparticles 


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Copyright information

© Humana Press Inc. 2005

Authors and Affiliations

  • Rahina Mahtab
    • 1
  • Catherine J. Murphy
    • 2
  1. 1.Department of Physical SciencesSouth Carolina State UniversityOrangeburg
  2. 2.Department of Chemistry and BiochemistryUniversity of South CarolinaColumbia

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