Abstract
Conformation-sensitive gel electrophoresis (CSGE) was initially developed by Ganguly et al. in 1993 as a screening method to minimize the amount of nucleotide sequencing required when investigating large multiexon genes for mutations (1). It is based on the ability to distinguish between homoduplexed and heteroduplexed DNA fragments by electrophoresis under partially denaturing conditions.
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References
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© 2005 Humana Press Inc., Totowa, NJ
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Hill, M. (2005). Conformation-Sensitive Gel Electrophoresis. In: Walker, J.M., Rapley, R. (eds) Medical Biomethods Handbook. Springer Protocols Handbooks. Humana Press. https://doi.org/10.1385/1-59259-870-6:147
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DOI: https://doi.org/10.1385/1-59259-870-6:147
Publisher Name: Humana Press
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