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Plasmonics-Based Nanostructures for Surface-Enhanced Raman Scattering Bioanalysis

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Protein Nanotechnology

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 300))

Summary

Surface-enhanced Raman scattering (SERS) spectroscopy is a plasmonics-based spectroscopic technique that combines modern laser spectroscopy with unique optical properties of metallic nanostructures, resulting in strongly increased Raman signals when molecules are adsorbed on or near nanometer-size structures of special metals such as gold, silver, and transition metals. This chapter provides a synopsis of the development and application of SERS-active metallic nanostructures, especially for the analysis of biologically relevant compounds. Some highlights of this chapter include reports of SERS as an immunoassay readout method, SERS gene nanoprobes, near-field scanning optical microscopy SERS probes, SERS as a tool for single-molecule detection, and SERS nanoprobes for cellular studies.

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Acknowledgments

This work was jointly sponsored by the Federal Bureau of Investigation (Project No. 2051-II18-Y1), and the Office of Biological and Environmental Research, U.S. Department of Energy, under contract DE-AC05-00OR22725 with UT-Battelle, LLC; and by the Laboratory Directed Research and Development Program (Advanced Plasmonics Sensors Project) at Oak Ridge National Laboratory. Fei Yan and David L. Stokes are also supported by an appointment to the Oak Ridge National Laboratory Postdoctoral Research Associates Program, administered jointly by the Oak Ridge National Laboratory and Oak Ridge Institute for Science and Education.

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Authors and Affiliations

  1. Center for Advanced Biomedical Photonics, Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN

    Tuan Vo-Dinh

  2. Center for Advanced Biomedical Photonics, Oak Ridge National Laboratory, Oak Ridge, TN

    Fei Yan & David L. Stokes

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  1. Tuan Vo-Dinh
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  2. Fei Yan
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  3. David L. Stokes
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Editors and Affiliations

  1. Center for Advanced Biomedical Photonics, Oak Ridge National Laboratory, Oak Ridge, TN

    Tuan Vo-Dinh (Director) (Director)

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Vo-Dinh, T., Yan, F., Stokes, D.L. (2005). Plasmonics-Based Nanostructures for Surface-Enhanced Raman Scattering Bioanalysis. In: Vo-Dinh, T. (eds) Protein Nanotechnology. Methods in Molecular Biology™, vol 300. Humana Press. https://doi.org/10.1385/1-59259-858-7:255

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  • DOI: https://doi.org/10.1385/1-59259-858-7:255

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-310-7

  • Online ISBN: 978-1-59259-858-8

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