Abstract
Nonviral gene delivery methods with naked plasmids and various plasmid carrier complexes have been used for intravascular, intramuscular and periadventitial gene delivery to cardiovascular system. Efficacy, homogenity and quality of the nonviral gene delivery complexes can be significantly affected by the way they are produced. This chapter presents basic methods to produce nonviral gene delivery complexes and describes common models to test their properties in cardiovascular applications in vivo.
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Ruponen, M., Hyvönen, Z., Urtti, A., Ylä-Herttuala, S. (2005). Nonviral Gene Delivery Methods in Cardiovascular Diseases. In: Fennell, J.P., Baker, A.H. (eds) Hypertension. Methods In Molecular Medicine™, vol 108. Humana Press. https://doi.org/10.1385/1-59259-850-1:315
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DOI: https://doi.org/10.1385/1-59259-850-1:315
Publisher Name: Humana Press
Print ISBN: 978-1-58829-323-7
Online ISBN: 978-1-59259-850-2
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