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Selection of Candidate Genes in Hypertension

  • Protocol
Hypertension

Part of the book series: Methods In Molecular Medicine™ ((MIMM,volume 108))

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Abstract

Essential hypertension is a common disease with multifactorial etiology affecting up to 10 million individuals in the United Kingdom alone. Current knowledge of the genetic contribution to this trait is restricted to a number of rare variants that produce hypertensive phenotypes in a Mendelian fashion and to genes highlighted by work on blood pressure regulation in rodent models. Recent advances in comparative genomics, genome-wide scans for linkage, transcriptomics, proteomics, and metabolomics allow a systematic approach to the prioritization of candidate genes for hypertension and other complex traits. We review the current state of play in these fields related to hypertension and show, with a particular example, how these data may help target genetic studies in the future.

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Authors
  1. A. Charles
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Editors and Affiliations

  1. Moyne Institute for Preventive Medicine, Trinity College, Dublin, Ireland

    Jérôme P. Fennell

  2. Division of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK

    Andrew H. Baker

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© 2005 Humana Press Inc.

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Charles, A. (2005). Selection of Candidate Genes in Hypertension. In: Fennell, J.P., Baker, A.H. (eds) Hypertension. Methods In Molecular Medicine™, vol 108. Humana Press. https://doi.org/10.1385/1-59259-850-1:107

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  • DOI: https://doi.org/10.1385/1-59259-850-1:107

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-323-7

  • Online ISBN: 978-1-59259-850-2

  • eBook Packages: Springer Protocols

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