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Hypertension pp 3–15Cite as

Congenic/Consomic Models of Hypertension

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Part of the book series: Methods In Molecular Medicine™ ((MIMM,volume 108))

Abstract

Human essential hypertension is a complex, multifactorial, quantitative trait under polygenic control. Despite major recent advances in genome sequencing and statistical tools, the genetic dissection of essential hypertension still provides a formidable challenge. Genetic models of essential hypertension such as the spontaneously hypertensive stroke-prone rat (SHRSP) provide the scientist with genetic homogeneity, not possible within a human population, to aid the search for causative genes. The principal strategy in the rat has been the identification of quantitative trait loci (QTL) responsible for blood-pressure regulation by genome-wide scanning. In this chapter we focus on congenic and consomic breeding strategies for the confirmation of QTL and the genetic dissection of the implicated regions.

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Author information

Authors and Affiliations

  1. BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK

    Delyth Graham, Martin W. McBride & Nicholas J. R. Brain

  2. BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK

    Anna F. Dominiczak

Authors
  1. Delyth Graham
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  2. Martin W. McBride
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  3. Nicholas J. R. Brain
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  4. Anna F. Dominiczak
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Editor information

Editors and Affiliations

  1. Moyne Institute for Preventive Medicine, Trinity College, Dublin, Ireland

    Jérôme P. Fennell

  2. Division of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK

    Andrew H. Baker

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© 2005 Humana Press Inc.

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Cite this protocol

Graham, D., McBride, M.W., Brain, N.J.R., Dominiczak, A.F. (2005). Congenic/Consomic Models of Hypertension. In: Fennell, J.P., Baker, A.H. (eds) Hypertension. Methods In Molecular Medicine™, vol 108. Humana Press. https://doi.org/10.1385/1-59259-850-1:003

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  • DOI: https://doi.org/10.1385/1-59259-850-1:003

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-323-7

  • Online ISBN: 978-1-59259-850-2

  • eBook Packages: Springer Protocols

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