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Pragmatic Target Discovery From Novel Gene to Functionally Defined Drug Target

The Interleukin-1 Story

  • Protocol
Stroke Genomics

Part of the book series: Methods in Molecular Medicine ((MIMM,volume 104))

Abstract

The pro-inflammatory cytokine interleukin-1 (IL-1) has been proposed as a mediator of the acute neurodegenerative changes that occur following stroke. This is based largely on experimental studies in rodents, in particular the marked reduction in ischemic cell death seen when IL-1 receptor antagonist (IL-1ra) is administered. Mechanisms of IL-1 action remain largely unknown, but they may involve complex effects on many cells including microglia, astrocytes, neurons, and endothelial cells. In light of this, IL-1ra is currently under consideration as a potential treatment for stroke and other neurodegenerative conditions.

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  1. School of Biological Sciences, University of Manchester, Manchester, UK

    Stuart McRae Allan

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  1. Stuart McRae Allan
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  1. AstraZeneca Pharmaceuticals Macclesfield, Cheshire, UK

    Simon J. Read

  2. Neurology Centre for Excellence in Drug Discovery GlaxoSmithKline Pharmaceuticals, Harlow, Essex, UK

    David Virley

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© 2005 Humana Press Inc., Totowa, NJ

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Allan, S.M. (2005). Pragmatic Target Discovery From Novel Gene to Functionally Defined Drug Target. In: Read, S.J., Virley, D. (eds) Stroke Genomics. Methods in Molecular Medicine, vol 104. Humana Press. https://doi.org/10.1385/1-59259-836-6:333

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  • DOI: https://doi.org/10.1385/1-59259-836-6:333

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-333-6

  • Online ISBN: 978-1-59259-836-6

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