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Introduction to Stroke Genomics

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Stroke Genomics

Part of the book series: Methods in Molecular Medicine ((MIMM,volume 104))

Abstract

Translation of the explosion in knowledge of acute ischemic stroke into satisfactory treatment regimens has yet to happen. At present tPA, intra-arterial prourokinase and low-molecular-weight heparin form the vanguard for therapeutic intervention, yet these treatments have a limited therapeutic window.

Part of this expansion in understanding has been driven by the contribution of stroke genetics and genomics. However, despite the enormous preclinical and clinical information of receptors, enzymes, second messenger systems, and so forth, that are implicated in stroke pathophysiology, delivery of novel drug treatment has been slow.

This introductory chapter discusses the multiple sources of clinical and preclinical genetic information. It will describe the importance of integrating expression information into multiple preclinical models with temporal and spatial roles in lesion pathology and, furthermore developing an understanding of function in the clinic before claiming a role in ischemic stroke.

The goal of such a holistic integration of information is to increase the yield from current datasets of gene expression and ultimately to help expand the choice of treatment available to the physician and patient.

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Author information

Authors and Affiliations

  1. AstraZeneca Pharmaceuticals, Macclesfield, Cheshire, UK

    Simon J. Read

  2. High-Throughput Biology, Discovery Research, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA

    Frank C. Barone

Authors
  1. Simon J. Read
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  2. Frank C. Barone
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Editor information

Editors and Affiliations

  1. AstraZeneca Pharmaceuticals Macclesfield, Cheshire, UK

    Simon J. Read

  2. Neurology Centre for Excellence in Drug Discovery GlaxoSmithKline Pharmaceuticals, Harlow, Essex, UK

    David Virley

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© 2005 Humana Press Inc., Totowa, NJ

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Read, S.J., Barone, F.C. (2005). Introduction to Stroke Genomics. In: Read, S.J., Virley, D. (eds) Stroke Genomics. Methods in Molecular Medicine, vol 104. Humana Press. https://doi.org/10.1385/1-59259-836-6:003

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  • DOI: https://doi.org/10.1385/1-59259-836-6:003

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-333-6

  • Online ISBN: 978-1-59259-836-6

  • eBook Packages: Springer Protocols

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