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Modulation of Drug Metabolism and Antiviral Therapies

  • Bernhard H. Lauterburg
Protocol
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Part of the Methods in Pharmacology and Toxicology book series (MIPT)

Abstract

Antiviral therapies are an important, emerging area of pharmaceutical research, particularly with the advent of the AIDS epidemic and the continued existence of other virally mediated diseases. This chapter focuses on pharmacological approaches to treat these diseases and summarizes the current classes of therapeutic agents. The concept of pharmacokinetic “boosting” in enhancing the efficacy of treatment is discussed, as is the interaction potential of clinically used antiviral agents and the role of intestinal metabolism and drug transporters, particularly the multidrug resistance proteins, in the handling of these drugs. Major classes of antiviral agents that are discussed include nucleoside and nucleotide analogs, other reverse-transcriptase inhibitors, protease inhibitors, fusion inhibitors, and interferons.

Key Words

Analogs: nucleoside analogs: nucleotide antiviral agents cytochrome P450 CYP2D6 CYP3A4 HIV-protease inhibitors interferons intestinal metabolism transport multidrug resistance proteins P-glycoprotein reverse-transcriptase: nonnucleoside inhibitors 

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Copyright information

© Humana Press Inc. 2005

Authors and Affiliations

  • Bernhard H. Lauterburg
    • 1
  1. 1.Department of Clinical PharmacologyUniversity of BernBernSwitzerland

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