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Autoimmunity pp 227–272Cite as

Experimental Use of Murine Lupus Models

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Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 102))

Summary

Murine models of systemic lupus erythematosus provide fertile research systems for the pathogenesis and therapy of systemic autoimmune disease. Their phenotypes span the broad range of clinical manifestations of human lupus and consist of both spontaneous and experimentally induced disease in both inbred and targeted mutant animals. This chapter contrasts the clinical characteristics of these various models, providing an outline for the use and analysis of these in vivo autoimmune systems.

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Authors and Affiliations

  1. Department of Internal Medicine/Rheumatology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO

    Stanford L. Peng

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  1. Stanford L. Peng
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  1. Departments of Medicine, Microbiology, and Immunology, State University of New York, Upstate Medical University, College of Medicine, Syracuse, NY

    Andras Perl MD, PhD

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© 2004 Humana Press Inc., Totowa, NJ

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Peng, S.L. (2004). Experimental Use of Murine Lupus Models. In: Perl, A. (eds) Autoimmunity. Methods in Molecular Medicine™, vol 102. Humana Press. https://doi.org/10.1385/1-59259-805-6:227

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  • DOI: https://doi.org/10.1385/1-59259-805-6:227

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-231-5

  • Online ISBN: 978-1-59259-805-2

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