Abstract
The single-pass perfused rat intestinal model is an in situ perfusion method that can be used to determine regional disposition of drugs. It is useful for selecting a development candidate from a series of active compounds and for studying mechanisms of absorption and excretion. It is also useful for determining if a compound may be appropriate for a sustained-release control formulation. The Food and Drug Administration (FDA) recognized the model system as a useful model to classify a compound’s absorption characteristics in the Biopharmaceutics Classification System. This model may be modified to determine the contribution of intestine versus liver in the disposition of a specific compound, both of which may be useful to determine the enteric and enterohepatic recycling of drugs.
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© 2004 Humana Press Inc., Totowa, NJ
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Jeong, E.J., Liu, Y., Lin, H., Hu, M. (2004). In Situ Single-Pass Perfused Rat Intestinal Model for Absorption and Metabolism. In: Yan, Z., Caldwell, G.W. (eds) Optimization in Drug Discovery. Methods in Pharmacology and Toxicology. Humana Press. https://doi.org/10.1385/1-59259-800-5:065
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DOI: https://doi.org/10.1385/1-59259-800-5:065
Publisher Name: Humana Press
Print ISBN: 978-1-58829-332-9
Online ISBN: 978-1-59259-800-7
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