Abstract
The fibrinogen receptor on platelets is glycoprotein (GP) IIb/IIIa, also known as αIIbβ3. This receptor can bind to immobilized fibrinogen in its resting state. Binding to soluble fibrinogen, however, requires activation of the receptor. This can occur due to inside-out signaling in response to a platelet agonist such as ADP, or directly by agents such as manganese. The interaction between GPIIb/IIIa and fibrinogen is essential in the formation of platelet aggregates (1,2).
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Cox, D. (2004). Ligand-Binding Assays. In: Gibbins, J.M., Mahaut-Smith, M.P. (eds) Platelets and Megakaryocytes. Methods in Molecular Biology™, vol 273. Humana Press. https://doi.org/10.1385/1-59259-783-1:125
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DOI: https://doi.org/10.1385/1-59259-783-1:125
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