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Mechanistic Dissection of Pain

From DNA to Animal Models

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Book cover Pain Research

Part of the book series: Methods in Molecular Medicine ((MIMM,volume 99))

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References

  1. Katz, N. (2002) The impact of pain management on quality of life. J. Pain Sympt. Manage 24, S38–47.

    Article  Google Scholar 

  2. Ophoff, R. A., Terwindt, G. M., Vergouwe, M. N., et al. (1996) Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channelgene CACNL1A4. Cell 87, 543–552.

    Article  PubMed  CAS  Google Scholar 

  3. Indo, Y., Tsuruta, M., Hayashida, Y., et al. (1996) Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. Nat Genet 13, 485–488.

    Article  PubMed  CAS  Google Scholar 

  4. Mogil, J. S., Yu, L., and Basbaum, A. I. (2000) Pain genes?: natural variation and transgenic mutants. Ann. Rev. Neurosci. 23, 777–811.

    Article  PubMed  CAS  Google Scholar 

  5. Woolf, C. J. and Decosterd, I. (1999) Implications of recent advances in the understanding of pain pathophysiology for the assessment of pain in patients. Pain Suppl 6, S141–147.

    Google Scholar 

  6. Edwards, P. W., Zeichner, A., Kuczmierczyk, A. R., and Boczkowski, J. (1985) Familial pain models: the relationship between family history of pain and current pain experience. Pain 21, 379–384.

    Article  PubMed  CAS  Google Scholar 

  7. Zatzick, D. F. and Dimsdale, J. E. (1990) Cultural variations in response to painful stimuli. Psychosom. Med. 52, 544–557.

    PubMed  CAS  Google Scholar 

  8. Bachiocco, V., Scesi, M., Morselli, A. M., and Carli, G. (1993) Individual pain history and familial pain tolerance models: relationships to post-surgical pain. Clin. J. Pain 9, 266–271.

    Article  PubMed  CAS  Google Scholar 

  9. Erlanger, J., and Gasser, H. S. (1924) The compound nature of the action current of nerve as disclosed by the cathode ray oscillograph. American Journal of Physiology 70, 624–666

    Google Scholar 

  10. Erlanger, J., and Gasser, H. S. (1930) The action potential in fibers of slow conduction in spinal roots and somatic nerves. Americal Journal of Physiology 92, 43–82

    Google Scholar 

  11. Perl, E. R. (1992) Function of Dorsal Root Ganglion Neurons: An Overview. in Sensory Neurons: Diversity, Development, and Plasticity (Scott, S. A., ed), Oxford University Press, New York, pp. 3–23

    Google Scholar 

  12. Melzack, R., and Wall, P. D. (1965) Pain mechanisms: a new theory. Science 150, 971–979

    Article  PubMed  CAS  Google Scholar 

  13. Lawson, S. N. (1992) Morphological and biochemical cell types of sensory neurons. in Sensory Neurons: Diversity, development, and plasticity (Scott, S. A., ed), Oxford University Press, New York, pp. 27–59

    Google Scholar 

  14. Watkins, L. R., and Maier, S. F. (2002) Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev 82, 981–1011

    PubMed  CAS  Google Scholar 

  15. Emmert-Buck, M. R., Bonner, R. F., Smith, P. D., Chuaqui, R. F., Zhuang, Z., Goldstein, S. R., Weiss, R. A., and Liotta, L. A. (1996) Laser capture microdissection [see comments]. Science 274, 998–1001

    Article  PubMed  CAS  Google Scholar 

  16. Kiss, L., Bennett, P. B., Uebele, V. N., Koblan, K. S., Kane, S. A., Neagle, B., and Schroeder, K. (2003) Hig throughput ion-channel pharmacology: Planar-Array-Based voltage clamp. ASSAY and Drug Development Technologies 1, 127

    Article  PubMed  CAS  Google Scholar 

  17. Safieh-Garabedian, B., Poole, S., Allchorne, A., Winter, J., and Woolf, C. J. (1995) Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia. British Journal of Pharmacology 115, 1265–1275

    PubMed  CAS  Google Scholar 

  18. Lewin, G. R., Rueff, A., and Mendell, L. M. (1994) Peripheral and central mechanisms of NGF-induced hyperalgesia. European Journal of Neuroscience 6, 1903–1912

    Article  PubMed  CAS  Google Scholar 

  19. McMahon, S. B., Bennett, D. L., Priestley, J. V., and Shelton, D. L. (1995) The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule [see comments]. Nature Medicine 1, 774–780

    Article  PubMed  CAS  Google Scholar 

  20. Mantyh, P. W., Rogers, S. D., Honore, P., Allen, B. J., Ghilardi, J. R., Li, J., Daughters, R. S., Lappi, D. A., Wiley, R. G., and Simone, D. A. (1997) Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor [see comments]. Science 278, 275–279

    Article  PubMed  CAS  Google Scholar 

  21. Lönnberg, H., and Vuorio, E. (1996) Towards genomic drug therapy with antisense oligonucleotides. Annals of Medicine 28, 511–522

    Article  PubMed  Google Scholar 

  22. Crooke, S. T. (1998) Antisense therapeutics. Biotechnology and Genetic Engineering Reviews 15, 121–157

    PubMed  CAS  Google Scholar 

  23. Nielsen, P. E., Egholm, M., and Buchardt, O. (1994) Peptide nucleic acid (PNA). ADNA mimic with a peptide backbone. Bioconjugate Chemistry 5, 3–7

    Article  PubMed  CAS  Google Scholar 

  24. Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., and Mello, C. C. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature (London) 391, 806–811.

    Article  CAS  Google Scholar 

  25. Sharp, P. A. (2001) RNA interference—2001. Genes Dev 15, 485–490.

    Article  PubMed  CAS  Google Scholar 

  26. Bosher, J. M., and Labouesse, M. (2000) RNA interference: genetic wand and genetic watchdog. Nat Cell Biol 2, E31–36.

    Article  PubMed  CAS  Google Scholar 

  27. Yang, D., Buchholz, F., Huang, Z., et al. (2002) Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells. Proc. Natl. Acad. Sci. USA 99, 9942–9947.

    Article  PubMed  CAS  Google Scholar 

  28. Orban, P. C., Chui, D., and Marth, J. D. (1992) Tissue-and site-specific DNA recombination in transgenic mice. Proc. Natl. Acad. Sci. USA 89, 6861–6865.

    Article  PubMed  CAS  Google Scholar 

  29. Katarova, Z., Mugnaini, E., Sekerkova, G., et al. (1998) Regulation of cell-type specific expression of lacZ by the 5-′flanking region of mouse GAD67 gene in the central nervous system of transgenic mice. Europ. J. Neurosci. 10, 989–999.

    Article  CAS  Google Scholar 

  30. Lakso, M., Sauer, B., Mosinger, B., Jr., et al. (1992) Targeted oncogene activation by site-specific recombination in transgenic mice. Proc. Natl. Acad. Sci. USA 89, 6232–6236.

    Article  PubMed  CAS  Google Scholar 

  31. Kühn, R., Schwenk, F., Aguet, M., and Rajewsky, K. (1995) Inducible gene targeting in mice. Science 269, 1427–1429.

    Article  PubMed  Google Scholar 

  32. Sauer, B. and Henderson, N. (1988) Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc. Natl. Acad. Sci. USA 85, 5166–5170.

    Article  PubMed  CAS  Google Scholar 

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© 2004 Humana Press Inc.

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Luo, Z.D. (2004). Mechanistic Dissection of Pain. In: Luo, Z.D. (eds) Pain Research. Methods in Molecular Medicine, vol 99. Humana Press. https://doi.org/10.1385/1-59259-770-X:001

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  • DOI: https://doi.org/10.1385/1-59259-770-X:001

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-103-5

  • Online ISBN: 978-1-59259-770-3

  • eBook Packages: Springer Protocols

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