Abstract
For many years, it has been recognized that elevated serum cholesterol is a risk factor associated with atherosclerosis and coronary heart disease, the latter being a major cause of death in Western countries. Numerous drugs that lower cholesterol have been used to treat hypocholesterolemic individuals (1). However, the undesirable side effects of these compounds have caused concerns about their therapeutic use (2). Ingestion of probiotic (beneficial for health) lactic acid bacteria (LAB) would possibly be a more natural method to decrease serum cholesterol in humans (3), as has been was reported (4,5).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Suckling, K. E., Benson, G. M., Bond, B., et al. (1991) Cholesterol lowering and bile acid excretion in the hamster with cholestyramine treatment. Atherosclerosis 89, 183–190.
Frick, M., Elo, O., and Haapa, K. (1987) Helsinki Heart Study: primary prevention trial with gemfibrozil in middle-aged men with dyslipemia. N. Engl. J. Med. 317, 1237–1245.
Lin, S. Y., Ayres, J. W., Winkler, W., and Sandine, W. E. (1989) Lactobacillus effects on cholesterol: in vitro and in vivo results. J. Dairy Sci. 72, 2885–2899.
Rodas, B. Z., Gilliland, S. E., and Maxwell, C. V. (1996) Hypocholesterolemic action of Lactobacillus acidophilus ATCC 43121 and calcium in swine with hypercholesterolemia induced by diet. J. Dairy Sci. 79, 2121–2128.
Mc Namara, D. J., Lowell, A. M., and Sabb, J. E. (1989) Effect of yogurt intake on plasma lipid and lipoprotein levels in normolipidemic males. Atherosclerosis 79, 167–171.
Taranto, M. P., Medici, M., Perdigón, G., Ruíz Holgado, A. P., and Valdez, G. F. (2000) Effect of Lacobacillus reuteri on the prevention of hypercholesterolemia in mice. J. Dairy Sci. 83, 401–403.
Taranto, M. P., Medici, M., Perdigón, G., Ruíz Holgado, A. P., and Valdez, G. F. (1998) Evidence of hypocholesterolemic effect of Lactobacillus reuteri in hypercholesterolemic mice. J. Dairy Sci. 81, 2336–2340
de Man, J. C., Rogosa, M., and Sharpe, M. E. (1960) A medium for the cultivation of lactobacilli. J. Appl. Bacteriol. 23, 130–135
Berg, R. D. (1979) Bacterial translocation from the intestines. Exp. Anim. 34, 1–16.
de Valdez, G. F. and Taranto, M. P. (2000) Probiotic properties of lactobacilli: cholesterol reduction and bile salt hydrolase activity. In: Food Microbiology Protocols. Methods in Molecular Biology (Walker, J., ed.). Humana, Totowa, NJ, pp. 173–181.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2004 Humana Press Inc. Totowa, NJ
About this protocol
Cite this protocol
Taranto, M.P., Perdigón, G., Médici, M., Font de Valdez, G. (2004). Animal Model for In Vivo Evaluation of Cholesterol Reduction by Lactic Acid Bacteria. In: Spencer, J.F.T., Ragout de Spencer, A.L. (eds) Public Health Microbiology. Methods in Molecular Biology, vol 268. Humana Press. https://doi.org/10.1385/1-59259-766-1:417
Download citation
DOI: https://doi.org/10.1385/1-59259-766-1:417
Publisher Name: Humana Press
Print ISBN: 978-1-58829-117-2
Online ISBN: 978-1-59259-766-6
eBook Packages: Springer Protocols