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Clinical Applications of Capillary Electrophoresis

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Clinical Applications of Capillary Electrophoresis

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 27))

Abstract

Capillary electrophoresis (CE) is a new and innovative technique that separates charged or uncharged molecules in a thin buffer-filled capillary by the application of a very high voltage. Separations by CE are extremely fast: Some are achieved in less than 5 min, with reproducibility studies often showing coefficient of variation (CVs) of <2%. The outstanding characteristic of CE is that it is an extremely sensitive technique. Early workers reported separations greater than 1 million theoretical plates per meter by CE, which is 10× the sensitivity of high-performance liquid chromatography (HPLC). The development of automated sample injection has meant that CE can be integrated into a clinical setting in which turnaround of accurate, cost-effective results are paramount.

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Author information

Authors and Affiliations

  1. Division of Laboratory Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia

    Margaret A. Jenkins

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  1. Margaret A. Jenkins
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Editor information

Editors and Affiliations

  1. Russells Hall Hospital, Dudley, West Midlands, UK

    Stephen M. Palfrey

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© 1999 Humana Press Inc.

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Jenkins, M.A. (1999). Clinical Applications of Capillary Electrophoresis. In: Palfrey, S.M. (eds) Clinical Applications of Capillary Electrophoresis. Methods in Molecular Medicine™, vol 27. Humana Press. https://doi.org/10.1385/1-59259-689-4:1

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  • DOI: https://doi.org/10.1385/1-59259-689-4:1

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-639-0

  • Online ISBN: 978-1-59259-689-8

  • eBook Packages: Springer Protocols

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