Gene Dosage in Capillary Electrophoresis

Prenatal Diagnosis of Down’s Syndrome and Rh D/d Genotyping
  • Pier Giorgio Righetti
  • Cecilia Gelfi
  • Gian Franco Cossu
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 27)


The first instrumentation for capillary zone electrophoresis (CZE) became available 10 years ago, and, since that time, interest in the technique has grown at a steady pace. However, although CZE has been embraced by a diverse scientific community that includes biochemists, chemists, and molecular biologists, acceptance of CZE by the clinical laboratory community has been markedly slower. Nevertheless, two recent monographs, devoted to this particular topic, testify to the growing interest of CZE in the clinical science (1,2). In these two special issues, some reviews are devoted specifically to the topic of DNA analysis (3, 4, 5, 6). Another issue of Electrophoresis, dedicated to reviews on general topics of CZE, has recently appeared (7). An additional number of recent reviews testify to the great interest in the use of CZE for analysis of DNA for diagnostic purposes (8, 9, 10, 11, 12, 13).


Capillary Zone Electrophoresis Liquid Polymer Ammonium Persulphate Mesityl Oxide Capillary Zone Electrophoresis Method 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press Inc. 1999

Authors and Affiliations

  • Pier Giorgio Righetti
    • 1
  • Cecilia Gelfi
    • 2
  • Gian Franco Cossu
    • 3
  1. 1.Department of Agricultural and Industrial BiotechnologiesUniversity of VeronaVeronaItaly
  2. 2.ITBACNRMilanoItaly
  3. 3.Department of ImmunohematologyOspedale Civile di SassariSassariItaly

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