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Cytotoxic Drug Resistance Mechanisms pp 39–52Cite as

Analysis of Apoptosis in Tissue Sections

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Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 28))

Abstract

The recognition over the past decade that apoptosis represents a critical element in cell number control in physiological and pathological situations has been well-reviewed (1–4). In addition there is increasing recognition that many of the effects of chemo- and radiotherapeutic agents are mediated by apoptosis (5–7). The seminal work of Kerr, Wyllie, and Currie (8), building upon the earlier observations of Glucksmann (9) and Saunders (10), should be read by those interested in assaying apoptosis because of the excellent photomicrographs that document the morphological features of the process. This is important, because despite considerable progress in the understanding of the mechanistic basis of apoptosis, morphological analysis remains unquestionably the “gold standard” for its assessment and quantitation.

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Authors and Affiliations

  1. Department of Molecular and Cellular Pathology, University of Dundee, Dundee, UK

    Vicki Save & Peter A. Hall

  2. CRC Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey, UK

    Philip J. Coates

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  1. Vicki Save
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  2. Philip J. Coates
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  3. Peter A. Hall
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Editor information

Editors and Affiliations

  1. University of Glasgow, Glasgow, UK

    Robert Brown

  2. BioMedEx, Killearn, UK

    Uta Böger-Brown

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© 1999 Humana Press Inc.

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Save, V., Coates, P.J., Hall, P.A. (1999). Analysis of Apoptosis in Tissue Sections. In: Brown, R., Böger-Brown, U. (eds) Cytotoxic Drug Resistance Mechanisms. Methods in Molecular Medicine™, vol 28. Humana Press. https://doi.org/10.1385/1-59259-687-8:39

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  • DOI: https://doi.org/10.1385/1-59259-687-8:39

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-603-1

  • Online ISBN: 978-1-59259-687-4

  • eBook Packages: Springer Protocols

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