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In Situ Hybridization Protocols pp 69–81Cite as

Released Chromatin or DNA Fiber Preparations for High-Resolution Fiber FISH

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Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 123))

Abstract

When combined with molecular analysis and immunocytological localization, fluorescence in situ hybridization (FISH) represents one of the most direct and precise experimental tools in current biological research (1-4). Direct visualization and in situ detection fill the gap between molecular analysis and cytological description and provide a new avenue for in vitro and in vivo comparison. Such a system facilitates the understanding of cellular events not only with respect to what and how, but also where and when.

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Author information

Authors and Affiliations

  1. Center for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, MI

    Henry H. Q. Heng

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  1. Henry H. Q. Heng
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Editor information

Editors and Affiliations

  1. RMIT University Bundoora, Victoria, Australia

    Ian A. Darby

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© 2000 Humana Press Inc.

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Heng, H.H.Q. (2000). Released Chromatin or DNA Fiber Preparations for High-Resolution Fiber FISH. In: Darby, I.A. (eds) In Situ Hybridization Protocols. Methods in Molecular Biology™, vol 123. Humana Press. https://doi.org/10.1385/1-59259-677-0:69

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  • DOI: https://doi.org/10.1385/1-59259-677-0:69

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-686-4

  • Online ISBN: 978-1-59259-677-5

  • eBook Packages: Springer Protocols

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