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Hepatitis B and D Protocols pp 163–173Cite as

Delivery of Hepatitis B Virus Therapeutic Agents Using Asialoglycoprotein Receptor-Based Liver-Specific Targeting

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Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 96))

Abstract

Many kinds of vectors for gene transfer have been developed in the last 20 yr. These include viral vectors such retroviruses (1,2), adenoviruses (3,4), and adeno-associated viruses (5); nonviral vectors utilizing cell-specific recognizing components (6,7); and lipid-mediated liposomes (8). Some of these gene-transfer methods have reached Phase I and II clinical trials, while others are still in the laboratory. This chapter focuses on protocols for the use of asialoglycoprotein receptor-based carriers to alter hepatitis B virus (HBV) viral replication in cell culture and animal models.

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Author information

Authors and Affiliations

  1. Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Farmington, CT

    Masayoshi Konishi, Catherine H. Wu & George Y. Wu

Authors
  1. Masayoshi Konishi
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  2. Catherine H. Wu
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  3. George Y. Wu
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Editor information

Editors and Affiliations

  1. Ribapharm Inc., Costa Mesa, CA

    Robert K. Hamatake PhD  & Johnson Y. N. Lau MD  & 

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© 2004 Humana Press Inc.

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Konishi, M., Wu, C.H., Wu, G.Y. (2004). Delivery of Hepatitis B Virus Therapeutic Agents Using Asialoglycoprotein Receptor-Based Liver-Specific Targeting. In: Hamatake, R.K., Lau, J.Y.N. (eds) Hepatitis B and D Protocols. Methods in Molecular Medicine™, vol 96. Humana Press. https://doi.org/10.1385/1-59259-670-3:163

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  • DOI: https://doi.org/10.1385/1-59259-670-3:163

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-108-0

  • Online ISBN: 978-1-59259-670-6

  • eBook Packages: Springer Protocols

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