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Hepatitis B and D Protocols pp 65–69Cite as

In Situ Detection of Hepatitis B Viral Antigens

An Immunohistochemical Approach

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Part of the book series: Methods in Molecular Medicine ((MIMM,volume 95))

Abstract

Hepatitis B virus (HBV) infection is the most common type of viral hepatitis, affecting more than 350 million people worldwide. To understand in detail the pathogenetic mechanisms involved and assess the value of antiviral therapy, the detection of HBV antigens and genome in the target organ, the liver, is essential.

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References

  1. Lau, J.Y.N. and Wright, T.L (1993) Molecular virology and pathogenesis of hepatitis B. Lancet 342, 1335–1340.

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  2. Lau, J. Y. N., Bird, G. L., Naoumov, N. V., and Williams, R. (1993) Hepatic HLA antigen display in chronic hepatitis B virus infection: relation to hepatic expression of HBV genome/gene products and liver histology. Dig. Dis. Sci. 38, 888–895.

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  3. Fang, J.W. S., Wu, P. C, Lai, C.L., Lo, C.K., Meager, A, and Lau, J.Y L. (1994) Hepatic expression of interferon-α in chronic hepatitis B virus infection. Dig. Dis. Sci. 39, 2014–2021.

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  4. Fang, J.W.S., Shen, W.W., Meager, A., and Lau, J.Y.N. (1996) Activation of the tumor necrosis factor-a system in the liver in chronic hepatitis B virus infection. Am. J. Gastroenterol. 91, 748–753.

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  5. Lau, J. Y. N., Davies, S. E., Bain V. G., et al. (1992) High level expression of hepatitis B viral antigens in fibrosing cholestatic hepatitis. Gastroenterology 102, 956–962.

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Author information

Authors and Affiliations

  1. Research and Development, Ribapharm, Inc, Costa Mesa, CA

    Jane W. S. Fang & Johnson Y. N. Lau (Former Chief Executive Officer)

Authors
  1. Jane W. S. Fang
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  2. Johnson Y. N. Lau
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Editor information

Editors and Affiliations

  1. Ribapharm Inc., Costa Mesa, CA

    Robert K. Hamatake PhD  & Johnson Y. N. Lau MD  & 

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© 2004 Humana Press Inc.

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Cite this protocol

Fang, J.W.S., Lau, J.Y.N. (2004). In Situ Detection of Hepatitis B Viral Antigens. In: Hamatake, R.K., Lau, J.Y.N. (eds) Hepatitis B and D Protocols. Methods in Molecular Medicine, vol 95. Humana Press. https://doi.org/10.1385/1-59259-669-X:65

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  • DOI: https://doi.org/10.1385/1-59259-669-X:65

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-105-9

  • Online ISBN: 978-1-59259-669-0

  • eBook Packages: Springer Protocols

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