Abstract
The technique of in situ hybridization was first developed to localize specific DNA sequences on chromosomes (1). This technique has subsequently been modified to detect viral nuclear acids in tissue sections. Information gathered from this type of study can help us to identify the site of viral replication at the subcellular level and to understand the relationship between viral expression and disease activity.
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References
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© 2004 Humana Press Inc.
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Lai, V.C.H., Lau, J.Y.N. (2004). In Situ Hybridization for the Detection and Localization of HBV DNA in Liver Sections. In: Hamatake, R.K., Lau, J.Y.N. (eds) Hepatitis B and D Protocols. Methods in Molecular Medicine, vol 95. Humana Press. https://doi.org/10.1385/1-59259-669-X:51
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DOI: https://doi.org/10.1385/1-59259-669-X:51
Publisher Name: Humana Press
Print ISBN: 978-1-58829-105-9
Online ISBN: 978-1-59259-669-0
eBook Packages: Springer Protocols