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Evaluation of Platelet Antagonists in In Vitro Flow Models of Thrombosis

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Anticoagulants, Antiplatelets, and Thrombolytics

Part of the book series: Methods In Molecular Medicine™ ((MIMM,volume 93))

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Abstract

Intravascular thrombosis is one of the most frequent pathological events that affects mankind, and a major cause of morbidity and mortality in developed countries. There is abundant evidence suggesting that platelets play a pivotal role in the pathogenesis of arterial thrombotic disorders, including unstable angina (UA), myocardial infarction (MI), and stroke (1–3). The underlying pathophysiological mechanism of these processes has been recognized as the disruption or erosion of a vulnerable atherosclerotic plaque, leading to local platelet adhesion and subsequent formation of partially or completely occlusive platelet thrombi.

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Author information

Authors and Affiliations

  1. Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD

    Owen J. T. McCarty, James P. Abulencia & Konstantinos Konstantopoulos

  2. Albany College of Pharmacy, Albany, NY

    Shaker A. Mousa

Authors
  1. Owen J. T. McCarty
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  2. James P. Abulencia
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  3. Shaker A. Mousa
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  4. Konstantinos Konstantopoulos
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Editor information

Editors and Affiliations

  1. Albany College of Pharmacy, Albany, NY

    Shaker A. Mousa

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© 2004 Humana Press Inc.

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McCarty, O.J.T., Abulencia, J.P., Mousa, S.A., Konstantopoulos, K. (2004). Evaluation of Platelet Antagonists in In Vitro Flow Models of Thrombosis. In: Mousa, S.A. (eds) Anticoagulants, Antiplatelets, and Thrombolytics. Methods In Molecular Medicine™, vol 93. Springer, Totowa, NJ. https://doi.org/10.1385/1-59259-658-4:21

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  • DOI: https://doi.org/10.1385/1-59259-658-4:21

  • Publisher Name: Springer, Totowa, NJ

  • Print ISBN: 978-1-58829-083-0

  • Online ISBN: 978-1-59259-658-4

  • eBook Packages: Springer Protocols

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