Abstract
Toward the end of the 1980s, two advances in the mass spectrometry (MS) of peptides and proteins were announced independently and, with ongoing developments, are still at the center of current methodologies (1). Both developments were the refinement and application of ionization techniques, namely electrospray and matrix-assisted laser desorption and ionization (MALDI), and both offered increased sensitivity and increased the upper mass limit of peptides or proteins amenable to mass spectrometry. Such was the impact of these techniques that the originators were awarded Nobel Prizes in 2002.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Reference
Cook, K. D. (2003). ASMS members John Fenn and Koichi Tanaka share Nobel: the world learns our “secret.” J. Am. Soc. Mass Spectrom. 13, 1359.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2004 Humana Press Inc., Totowa, NJ
About this protocol
Cite this protocol
Bell, D.J. (2004). Mass Spectrometry. In: Cutler, P. (eds) Protein Purification Protocols. Methods in Molecular Biology, vol 244. Humana Press. https://doi.org/10.1385/1-59259-655-X:447
Download citation
DOI: https://doi.org/10.1385/1-59259-655-X:447
Publisher Name: Humana Press
Print ISBN: 978-1-58829-067-0
Online ISBN: 978-1-59259-655-3
eBook Packages: Springer Protocols