Abstract
In order to perform neurotoxicological studies, model systems have to be established and techniques developed to analyze relevant parameters. The present chapter describes the in vitro effects of the neurotoxicants aminooxyacetic acid (AOAA), 3-nitropropionic acid (3-NPA), and methylmercury (MeHg) on glial cell neurotransmitters, and for 3-NPA, we also describe the effects on cultured neurons. Major emphasis is directed at the effects of these compounds on glutamate metabolism.
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Aschner, M., Sonnewald, U. (2004). Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants. In: Tiffany-Castiglioni, E., Hollinger, M.A. (eds) In Vitro Neurotoxicology. Methods in Pharmacology and Toxicology. Humana Press. https://doi.org/10.1385/1-59259-651-7:133
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