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Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants

Enzyme Pathways in Neurons and Astroglia

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In Vitro Neurotoxicology

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

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Abstract

In order to perform neurotoxicological studies, model systems have to be established and techniques developed to analyze relevant parameters. The present chapter describes the in vitro effects of the neurotoxicants aminooxyacetic acid (AOAA), 3-nitropropionic acid (3-NPA), and methylmercury (MeHg) on glial cell neurotransmitters, and for 3-NPA, we also describe the effects on cultured neurons. Major emphasis is directed at the effects of these compounds on glutamate metabolism.

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC

    Michael Aschner (Professor)

  2. Department of Clinical Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway

    Ursula Sonnewald (Professor)

Authors
  1. Michael Aschner
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  2. Ursula Sonnewald
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Editors and Affiliations

  1. Department of Veterinary Anatomy and Public Health, Texas A&M University College of Veterinary Medicine, College Station, TX

    Evelyn Tiffany-Castiglioni

  2. Center for Environmental and Rural Health, College Station, TX

    Evelyn Tiffany-Castiglioni

  3. University of California, Davis, CA

    Mannfred A. Hollinger

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Aschner, M., Sonnewald, U. (2004). Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants. In: Tiffany-Castiglioni, E., Hollinger, M.A. (eds) In Vitro Neurotoxicology. Methods in Pharmacology and Toxicology. Humana Press. https://doi.org/10.1385/1-59259-651-7:133

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  • DOI: https://doi.org/10.1385/1-59259-651-7:133

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-047-2

  • Online ISBN: 978-1-59259-651-5

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