Abstract
The efficient transduction of postmitotic cells by adeno-associated virus (AAV) makes it an excellent vector to deliver marker, functional, or therapeutic genes to the mammalian brain. An attractive feature of AAV is that all the viral-coding sequences are removed when engineering the recombinant genome, thereby limiting the extent of cell toxicity and immune response that are often associated with viral gene transcription (1).
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Passini, M.A., Watson, D.J., Wolfe, J.H. (2004). Gene Delivery to the Mouse Brain with Adeno-Associated Virus. In: Heiser, W.C. (eds) Gene Delivery to Mammalian Cells. Methods in Molecular Biology™, vol 246. Humana Press. https://doi.org/10.1385/1-59259-650-9:225
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DOI: https://doi.org/10.1385/1-59259-650-9:225
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