Chiral Separations by Capillary Electrophoresis Using Cinchona Alkaloid Derivatives as Chiral Counter-Ions
Cinchona alkaloids and derivatives thereof, obtained by dedicated structural modifications, have a long tradition in various stereochemical methods. Among them, their stereoselective ion-pairing capabilities for acidic compounds have been exploited for capillary electrophoretic enantiomer separations of chiral acids (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14).
KeywordsChiral Selector Octanoic Acid Cinchona Alkaloid Filling Technique Plug Length
- 8.Lämmerhofer, M., Zarbl, E., Lindner, W., Peric Simov, B., and Hammerschmidt, F. (2001) Simultaneous separation of the stereoisomers of 1-amino-2-hydroxy and 2-amino-1-hydroxypropane phosphonic acids by stereoselective capillary electrophoresis employing a quinine carbamate type chiral selector. Electrophoresis 22, 1182–1187.Google Scholar
- 9.Hammerschmidt, F., Lindner, W., Wuggenig, F., and Zarbl, E. (2000) Enzymes in organic chemistry. Part 10: chemo-enzymatic synthesis of L-phosphaserine and L-phosphaisoserine and enantioseparation of amino-hydroxyethylphosphonic acids by non-aqueous capillary electrophoresis with quinine carbamate as chiral ion pair agent. Tetrahedron: Asymmetry 11, 2955–2964.CrossRefGoogle Scholar
- 13.Peric Simov, B., Wuggenig, F., Lämmerhofer, M., Lindner, W., Zarbl, E., and Hammerschmidt, F. (2002) Indirect evidence for the biosynthesis of (1S,2S)-1,2-epoxypropylphosphonic acid as a Co-metabolite of fosfomycin [(1R,2S)-1,2-epoxy-propylphosphonic acid] by Streptomyces fradiae. Eur. J. Org. Chem. 1139–1142.Google Scholar
- 15.Budavari, S. (ed.) (1989) The Merck Index. Merck & Co., Rahway, NJ.Google Scholar