Abstract
The lipase gene family comprises three vertebrate genes, lipoprotein lipase (LPL), hepatic lipase (HL) and pancreatic lipase (PL), that are derived from a common ancestral gene. While these lipases are functionally related, considerable evidence indicates that LPL and HL share a higher degree of structural homology than either shares with PL (1–4). For example, it has been established by a number of different methods that LPL and HL are functionally active as homodimers, while PL is active as a monomer (5–9). However, there are discrepancies reported in the literature, namely the findings of monomeric functional units of LPL and HL by Ikeda et al. (10) and Schoonderwoerd et al. (11), the latter concluding that the functional unit of rat HL in the liver is a monomer, while in adrenal gland and ovary it might be a dimer.
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Ben-Zeev, O., Doolittle, M.H. (1999). Determining Lipase Subunit Structure by Sucrose Gradient Centrifugation. In: Doolittle, M., Reue, K. (eds) Lipase and Phospholipase Protocols. Methods in Molecular Biology™, vol 109. Humana Press. https://doi.org/10.1385/1-59259-581-2:257
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DOI: https://doi.org/10.1385/1-59259-581-2:257
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