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Construction of VNP20009

A Novel, Genetically Stable Antibiotic-Sensitive Strain of Tumor-Targeting Salmonella for Parenteral Administration in Humans

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Suicide Gene Therapy

Part of the book series: Methods in Molecular Medicineā„¢ ((MIMM,volume 90))

Abstract

The engineering of tumor-targeting Salmonella strains bearing a high degree of both attenuation and tumor inhibition is a recently developed approach to vector-based treatment of cancer (1,2). Tumor-targeted Salmonella have many desirable features for a tumor-selective delivery vehicle:

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Notes

  1. 1.

    *

    In these discussions, we refer to all nonanimal experiments as in vitro, regardless of the use of live bacteria and/or mammalian cells

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Ā© 2004 Humana Press Inc.

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Low, K.B. et al. (2004). Construction of VNP20009. In: Springer, C.J. (eds) Suicide Gene Therapy. Methods in Molecular Medicineā„¢, vol 90. Humana Press. https://doi.org/10.1385/1-59259-429-8:47

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  • DOI: https://doi.org/10.1385/1-59259-429-8:47

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-971-1

  • Online ISBN: 978-1-59259-429-0

  • eBook Packages: Springer Protocols

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